A review on anti-leishmanial activity of terpenes and chitosan as a carrier for nano-formulations

IF 0.6 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Current Traditional Medicine Pub Date : 2023-07-27 DOI:10.2174/2215083810666230727094905

Deepali Bansode, Tanvi Goel

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Abstract

Leishmaniasis is one of the most devastating and fatal diseases in humans that has been known to mankind and is caused by the parasite Leishmania. It is destructive since no vaccination is available and existing medicines are proving ineffective because of resistance development. A need for the discovery of newer drugs has emerged. The use of natural products for the prevention, diagnosis, and cure of diseases has rapidly increased. Following the trend, research in the field of natural products for treating leishmaniasis has also picked up. In the present review, the focus is on terpenes as anti-leishmanial agents. Terpenes are the least studied natural products for the treatment of the disease. The other part of the review covers the use of chitosan as an anti-leishmanial agent and other formulations of chitosan as a carrier in nano-formulations. From the survey, it was found that the essential oils containing terpenes are very effective. Moreover, the chitosan-based nanocarriers showed potent anti-leishmanial activity. The combined use of natural products and newer technologies for the delivery of drugs can eradicate various diseases.

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以萜烯和壳聚糖为载体的纳米制剂抗利什曼原虫活性研究进展

利什曼病是人类已知的最具破坏性和最致命的人类疾病之一，由寄生虫利什曼原虫引起。它具有破坏性，因为没有疫苗接种，而且由于耐药性的发展，现有药物被证明是无效的。发现新药的需求已经出现。天然产品在疾病预防、诊断和治疗方面的应用迅速增加。随着这一趋势，治疗利什曼病的天然产物领域的研究也有所增加。在本文的综述中，重点是萜烯作为抗利什曼病的药物。萜烯是用于治疗这种疾病的研究最少的天然产物。另一部分综述了壳聚糖作为抗利什曼病剂的应用以及壳聚糖作为纳米制剂载体的其他剂型。从调查中发现，含有萜烯的精油非常有效。此外，壳聚糖基纳米载体具有较强的抗利什曼原虫活性。结合使用天然产物和较新的给药技术可以根除各种疾病。

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来源期刊

Current Traditional Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Traditional Medicine covers all the aspects of the modernization and standardization research on traditional medicine of the world, e.g. chemistry, pharmacology, molecular mechanism, systems biology, proteomics, genomics, metabolomics, safety, quality control, clinical studies of traditional Chinese, Ayurvedic, Unani, Arabic and other ethnomedicine. Each issue contains updated comprehensive in-depth/mini reviews along with high quality original experimental research articles. Current Traditional Medicine is a leading and important international peer-reviewed journal reflecting the current outstanding scientific research progresses of the global traditional, indigenous, folk and ethnologic medicine. It provides a bridge connected the tradition medicine system to the modern life science with the efforts of top scientists, as well as a resource to pursuit the solutions for the existing common issues in the traditional medicine.