{"title":"Lipid signaling in chemotherapy-induced peripheral neuropathy","authors":"Shota Yamamoto , Nobuaki Egashira","doi":"10.1016/j.cotox.2021.08.007","DOIUrl":null,"url":null,"abstract":"<div><p>Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs<span>. However, there are few options for the prevention and treatment of CIPN. Lipids<span><span> play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of </span>lipid signaling in CIPN pathology.</span></span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 1-6"},"PeriodicalIF":6.1000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.007","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202021000425","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs. However, there are few options for the prevention and treatment of CIPN. Lipids play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of lipid signaling in CIPN pathology.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
