Transcriptome alterations and therapeutic drugs in different organs after spinal cord injury based on integrated bioinformatic analysis

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY Journal of Neurorestoratology Pub Date : 2023-06-01 DOI:10.1016/j.jnrt.2023.100056

Haoru Dong , Donglei Shi , Yifeng Bao , Xingyu Chen , Longnian Zhou , Haiyue Lin , Yuanqing Ding , Jinping Liu , Jian Yu , Rong Xie

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Abstract

Objective

To identify transcriptomic alterations and therapeutic drugs in different organs after spinal cord injury via comprehensive bioinformatics analyses.

Methods

RNA-sequencing data of the soleus muscle, bladder, liver, raphe, and sensorimotor cortex areas in various rat spinal cord injury models were obtained from the Gene Expression Omnibus database for bioinformatics analysis. Then, the common pathways and biological pathway changes in multiple organs were identified.

Results

By comparing the enrichment results of differentially expressed genes, inflammatory response and lipid metabolism were found to be significantly altered in multiple organs. The MAPK signaling pathway was a key pathway in the abovementioned biological processes. In addition, autonomous repair was observed in each organ. Finally, pharmacological analysis showed that coenzyme A might be an effective drug.

Conclusion

Coenzyme A is a candidate treatment drug for spinal cord injury. Hence, in addition to the current mechanisms targeted by anti-inflammatory approaches, lipid metabolism can also be a treatment target for spinal cord injury.

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基于生物信息学综合分析的脊髓损伤后不同器官转录组变化及治疗药物

目的通过综合生物信息学分析，确定脊髓损伤后不同器官的转录组改变和治疗药物。方法从基因表达综合数据库中获取不同脊髓损伤模型大鼠比目鱼肌、膀胱、肝脏、中缝和感觉运动皮层区域的RNA测序数据，进行生物信息学分析。然后，确定了多个器官中的常见途径和生物途径变化。结果通过比较差异表达基因的富集结果，发现多个器官的炎症反应和脂质代谢发生了显著变化。MAPK信号通路是上述生物学过程中的关键通路。此外，在每个器官中都观察到自主修复。最后，药理分析表明辅酶A可能是一种有效的药物。结论辅酶A是治疗脊髓损伤的候选药物。因此，除了目前抗炎方法靶向的机制外，脂质代谢也可以成为脊髓损伤的治疗靶点。

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