Patient-specific dendritic cell vaccines with autologous tumor antigens in 72 patients with metastatic melanoma

IF 1 Q4 ONCOLOGY Melanoma Management Pub Date : 2019-05-31 DOI:10.2217/mmt-2018-0010

R. Dillman, A. Cornforth, E. McClay, C. Depriest

引用次数: 9

Abstract

Aim: Metastatic melanoma patients were treated with patient-specific vaccines consisting of autologous dendritic cells loaded with antigens from irradiated cells from short-term autologous tumor cell lines. Patients & methods: A total of 72 patients were enrolled in a single-arm Phase I/II (NCT00948480) trial or a randomized Phase II (NCT00436930). Results: Toxicity was minimal. Median overall survival (OS) was 49.4 months; 5-year OS 46%. A 5-year OS was 72% for 18 recurrent stage 3 without measurable disease when treated and 53% for 30 stage 4 without measurable disease when treated. A total of 24 patients with measurable stage 4 when treated (median of four prior therapies) had an 18.5 months median OS and 46% 2-year OS. Conclusion: This dendritic cell vaccine was associated with encouraging survival in all three clinical subsets. Clinicaltrial.gov NCT00436930 and NCT00948480.

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具有自体肿瘤抗原的患者特异性树突状细胞疫苗治疗72例转移性黑色素瘤

目的：用患者特异性疫苗治疗转移性黑色素瘤患者，该疫苗由自体树突状细胞组成，该细胞负载来自短期自体肿瘤细胞系的辐照细胞的抗原。患者和方法：共有72名患者参加了一项单臂I/II期（NCT00948480）试验或一项随机II期试验（NCT00436930）。结果：毒性最小。中位总生存期（OS）为49.4个月；5年OS 46%。18例无可测量疾病的复发性3期患者在治疗时的5年OS为72%，30例无可测疾病的4期患者在处理时的5月OS为53%。共有24名可测量的4期患者在接受治疗时（之前四次治疗的中位数）有18.5个月的中位OS和46%的2年OS。结论：该树突状细胞疫苗可促进所有三个临床亚群的存活。Clinicaltrial.gov NCT00436930和NCT00948480。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.