Orientation-Specific Plasmonic Biosensor for Alzheimer’s Disease Detection Using Graphene-Wrapped Au Nano ellipsoids

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Plasmonics Pub Date : 2023-09-06 DOI:10.1007/s11468-023-02006-5
Radhika V. Nair, Anandajith T. S., Anagha Umesh Menon
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Abstract

Ellipsoidal plasmonic particles are of huge importance in the biosensing field due to their orientation-specific light scattering properties and higher area of surface-adhesive interactions. In this paper, we present a computational investigation of the orientation-specific plasmonic properties of graphene-wrapped—Au nano ellipsoids of various aspect ratios and graphene layer thicknesses using the discontinuous Galerkin time domain (DGTD) method. We could observe that both the dipolar and quadrapolar resonances of Au ellipsoids are strongly modulated by graphene layer. Furthermore, we have modelled graphene wrapped Au ellipsoidal nanoarray biosensor with optimized orientation having very high sensitivity (484 nm/RIU) towards refractive index changes associated with various fibrillation stages of beta amyloid (biomarker for Alzheimer’s disease) compared to the bare Au nanoellipsoidal biosensor.

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用石墨烯包裹金纳米椭球体检测阿尔茨海默病的定向等离子体生物传感器
椭球质子粒子因其特定取向的光散射特性和较高的表面粘附相互作用面积而在生物传感领域具有重要意义。本文采用非连续伽勒金时域(DGTD)方法,对不同长宽比和石墨烯层厚度的石墨烯包裹金纳米椭球体的特定取向等离子特性进行了计算研究。我们可以观察到,金椭圆体的双极性和四极性共振都受到石墨烯层的强烈调制。此外,我们还模拟了石墨烯包裹的金椭球纳米阵列生物传感器,与裸金纳米椭球生物传感器相比,该传感器具有优化的取向,对与不同纤化阶段的贝塔淀粉样蛋白(老年痴呆症的生物标志物)相关的折射率变化具有极高的灵敏度(484 nm/RIU)。
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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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