Thilini N. Jayasinghe , Craig Hilton , Peter Tsai , Billy Apple , Peter Shepherd , Wayne S. Cutfield , Justin M. O'Sullivan
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引用次数: 8
Abstract
There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised the gut microbial composition of artist Billy Apple® from stool samples collected 45 years apart in 1970 and 2016. We observed that 45% of the microbial species were retained over the 45 year interval. Moreover, components of Apple’s microbiome associated with the allele frequency at seven SNPs in his genome. Collectively, our results are consistent with a genetic component contributing to the selection and maintenance of core members within the artist’s microbiome over his life-time.
期刊介绍：
The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.
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