Faecal Transplant Therapy: A Promising Treatment Modality for Cardiovascular Diseases

Pushkala K, Gupta Purshottam D
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Abstract

Cardiovascular diseases (CVD) are considered as “lifestyle” diseases and so far “No unified procedure” or medicines are effective in the management of this group of diseases. Researchers and clinicians have indicated that no safe therapeutic window is available in therapeutics at present. Recent research showed that gut microbiota are effective in managing lifestyle diseases therefore we introduced the influence of gut microbiota in the prognosis of the CVDs. Faecal transplant therapy(FMT) has been anticipated to treat many diseases similar to recurrent bacterial Clostridioides difficile infection which has been used worldwide. Recently, FMT was tried on an animal model to treat CVDs, and recent human trials that were tried to manage CVDs in humans by FMT showed encouraging results. The mechanism of action of transplanted bacteria to manage CVDs in the human population is also discussed. In-depth knowledge on the pros and cons of FMT will pave the way to standardize the procedure once the lacuna existing at present in treating CVDs, is paved, this technology will be useful for the masses.
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粪便移植治疗:心血管疾病的一种有前途的治疗方式
心血管疾病(CVD)被认为是一种“生活方式”疾病,迄今为止,“没有统一的程序”或药物有效地管理这类疾病。研究人员和临床医生指出,目前在治疗方法中没有安全的治疗窗口。最近的研究表明,肠道菌群在控制生活方式疾病方面是有效的,因此我们介绍了肠道菌群对心血管疾病预后的影响。粪便移植疗法(FMT)有望治疗许多类似于复发性难辨梭菌感染的疾病,这种疾病已在世界范围内得到应用。最近,FMT在动物模型上进行了治疗心血管疾病的试验,最近试图通过FMT治疗人类心血管疾病的人体试验显示出令人鼓舞的结果。本文还讨论了移植细菌控制人群心血管疾病的作用机制。深入了解FMT的利弊将为规范程序铺平道路,一旦填补了目前治疗心血管疾病的空白,这项技术将对大众有用。
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