Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament-bone interface

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2021-08-13 DOI:10.1049/bsb2.12021
Nan Jiang, Mao Mao, Xiao Li, Weijie Zhang, Jiankang He, Dichen Li
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引用次数: 1

Abstract

The natural ligament–bone interface features gradient changes in matrix composition, architecture and cell phenotype, which play critical roles in reliable ligament fixation and smooth loading transfer. Mimicking such organisations in artificial composite tissue-engineering scaffolds is important for realising functional fixation between ligament implants and host bones. Here, the authors aim to provide a comprehensive review on the latest strategies to fabricate biomimetic composite scaffolds for the regeneration of ligament-to-bone interface. The biomimetic composite scaffolds are divided into stratified and gradient scaffolds, which are characterised as layer-specific and continuous changes, respectively, in scaffold materials and/or microstructures. Biofabrication strategies for different types of composite scaffolds are summarised. The effects of material/structural changes on cellular morphology, cell differentiation, in vivo osteointegration and multi-tissue interface regeneration are highlighted. Finally, the potential challenges and future perspectives in engineering biomimetic composite scaffolds for ligament–bone interface regeneration are discussed.

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韧带-骨界面再生仿生复合支架的先进生物制造策略
天然的韧带-骨界面在基质组成、结构和细胞表型上具有梯度变化,这在可靠的韧带固定和平稳的负载转移中起着关键作用。在人工复合组织工程支架中模拟这些组织对于实现韧带植入物与宿主骨之间的功能固定非常重要。本文就韧带-骨界面再生仿生复合支架的最新研究进展进行综述。仿生复合支架分为分层支架和梯度支架,其特征分别是支架材料和/或微观结构的层特异性和连续变化。综述了不同类型复合支架的生物制造策略。强调了材料/结构变化对细胞形态、细胞分化、体内骨整合和多组织界面再生的影响。最后,讨论了用于韧带-骨界面再生的工程仿生复合材料支架的潜在挑战和未来前景。
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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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