A celiac disease marker: Serum immunoglobulin a anti-tissue transglutaminase in vitiligo cases and controls in a hospital in South-West Nigeria

Adetokunbo Ajala, Omowunmi Ashaolu, C. Olowu
{"title":"A celiac disease marker: Serum immunoglobulin a anti-tissue transglutaminase in vitiligo cases and controls in a hospital in South-West Nigeria","authors":"Adetokunbo Ajala, Omowunmi Ashaolu, C. Olowu","doi":"10.4103/njm.njm_106_22","DOIUrl":null,"url":null,"abstract":"Background: Vitiligo is an autoimmune disorder resulting from the destruction of melanocytes of affected patients. Celiac disease (CD) is characterised by autoimmune inflammation of small intestinal mucosa specifically triggered by the gluten consumption in susceptible individuals. Immunoglobulin A (IgA) anti-tissue transglutaminase (anti-tTG) serology is recommended as an initial test for the diagnosis of CD prior to confirmation with intestinal biopsy. Aim: We aimed to compare the serum IgA anti-tTG levels in vitiligo patients and controls without vitiligo in a hospital in South-West Nigeria. Materials and Methods: The study was a case–control study of 33 vitiligo cases and 33 controls. IgA anti-tTG was assayed in participants' sera using an enzyme-linked immunosorbent assay protocol employing recombinant human tTG. Results: A total of 66 participants were recruited into the study; 33 cases with vitiligo and 33 controls. The median age for cases was 50 years (range: 4–82). The median age for the controls was 55 years (range: 23–76). Generalised vitiligo accounted for 13 (40%) of vitiligo cases with the others consisting of various forms of segmental vitiligo. Anti-tTG levels were higher in cases at 6.1U/ml (8.8, 0.6–20.0) (med [interquartile range (IQR), min-max]), compared to controls 5.2 U/ml (3.7, 0.7–22.4). Difference between groups estimated using the Mann-Whitney U-test was not significant, u = 408.0, P = 0.08 (α = 0.05). Conclusion: There was no significant difference in serum IgA anti-tTG in vitiligo cases and controls in this study. Further studies are required to clarify the nature of the association between vitiligo and CD.","PeriodicalId":52572,"journal":{"name":"Nigerian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/njm.njm_106_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Vitiligo is an autoimmune disorder resulting from the destruction of melanocytes of affected patients. Celiac disease (CD) is characterised by autoimmune inflammation of small intestinal mucosa specifically triggered by the gluten consumption in susceptible individuals. Immunoglobulin A (IgA) anti-tissue transglutaminase (anti-tTG) serology is recommended as an initial test for the diagnosis of CD prior to confirmation with intestinal biopsy. Aim: We aimed to compare the serum IgA anti-tTG levels in vitiligo patients and controls without vitiligo in a hospital in South-West Nigeria. Materials and Methods: The study was a case–control study of 33 vitiligo cases and 33 controls. IgA anti-tTG was assayed in participants' sera using an enzyme-linked immunosorbent assay protocol employing recombinant human tTG. Results: A total of 66 participants were recruited into the study; 33 cases with vitiligo and 33 controls. The median age for cases was 50 years (range: 4–82). The median age for the controls was 55 years (range: 23–76). Generalised vitiligo accounted for 13 (40%) of vitiligo cases with the others consisting of various forms of segmental vitiligo. Anti-tTG levels were higher in cases at 6.1U/ml (8.8, 0.6–20.0) (med [interquartile range (IQR), min-max]), compared to controls 5.2 U/ml (3.7, 0.7–22.4). Difference between groups estimated using the Mann-Whitney U-test was not significant, u = 408.0, P = 0.08 (α = 0.05). Conclusion: There was no significant difference in serum IgA anti-tTG in vitiligo cases and controls in this study. Further studies are required to clarify the nature of the association between vitiligo and CD.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
乳糜泻标志物:尼日利亚西南部一家医院白癜风病例和对照的血清免疫球蛋白A抗组织转谷氨酰胺酶
背景:白癜风是一种自身免疫性疾病,由受影响患者的黑色素细胞破坏引起。乳糜泻(CD)的特征是易感个体的麸质消耗特别引发的小肠粘膜自身免疫性炎症。免疫球蛋白A(IgA)抗组织谷氨酰胺转胺酶(anti-tTG)血清学被推荐为在肠道活检确认之前诊断CD的初步测试。目的:我们旨在比较尼日利亚西南部一家医院白癜风患者和非白癜风对照组的血清IgA抗tTG水平。材料和方法:本研究为33例白癜风病例和33例对照研究。使用重组人tTG的酶联免疫吸附测定方案在参与者血清中测定IgA抗tTG。结果:本研究共招募了66名参与者;白癜风33例,对照组33例。病例的中位年龄为50岁(范围:4-82)。对照组的中位年龄为55岁(范围:23-76岁)。全身性白癜风占白癜风病例的13例(40%),其他病例包括各种形式的节段性白癜风。与对照组5.2 U/ml(3.7,0.7–22.4)相比,6.1U/ml(8.8,0.6–20.0)(med[四分位间距(IQR),最小-最大])的病例的抗tTG水平更高。使用Mann-Whitney U型检验估计的组间差异不显著,U=408.0,P=0.08(α=0.05)。结论:本研究中白癜风病例和对照组的血清IgA抗tTG没有显著差异。需要进一步的研究来阐明白癜风和CD之间的关系的性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
65
审稿时长
20 weeks
期刊介绍: The Nigerian Journal of Medicine publishes articles on socio-economic, political and legal matters related to medical practice; conference and workshop reports and medical news.
期刊最新文献
Knowledge of common cardiovascular diseases and its risk factors among members of a community in South-South Nigeria Prevalence, associated factors, and outcomes of singleton preterm births at a Tertiary Hospital in Port-Harcourt, Nigeria Assessment of factors affecting treatment adherence in patients with chronic kidney disease in Nigeria: A survey from a tertiary health-care centre Oral Neurofibroma: 10-Year Experience in Enugu A community survey of the vaccination status of under-five children in a community in Southern Nigeria
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1