Synthesis, Characterization and Evaluation Antibacterial Activity of Some Schiff Bases and (1,3-Oxazepine or Diazepine-4,7-Dione)

Abstract

In this study, some of Schiff bases, 1,3-oxazepine-4,7-dione and 1,3-diazepine-4,7-dione compounds derived from terephthalaldehyde and substituted aniline have been prepared, Schiff bases (a1-5) which derived from terephthalaldehyde and substituted aniline have been reacted with maleic anhydride and phthalic anhydride to produce 1,3-oxazepine-4,7-dione compounds (b1-10). 1,3-oxazepine-4,7-dione compounds (b1-10) have been reacted with phenyl hydrazine to produce 1,3-diazepine-4,7-dione compounds (c1-10). The prepared compounds were characterized using physical methods, the precise analysis of elements (C.H.N), infrared (IR) and ( 1 H NMR) spectroscopy. The reactions were monitored by. Thin Layer Chromatography (TLC). The antibacterial activity was evaluated for some of the synthesis compounds.