J. Mehrzad, T. Zahraei Salehi, A. Khosravi, S. Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, M. Moazenchi, A. Malvandi
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引用次数: 2
Abstract
Abstract Mycotoxins, especially carcinogenic aflatoxins (AFs), AFs B1-and-M1, are common contaminants of foodchains, damaging exposed hosts. We analyzed the effects of naturally-occurring levels of AFB1-and-AFM1 on the rat pancreatic islets from various healthy rats and exposed for 24 and 48 h to 10–20 ng of each AF/mL. The exposed islets were analyzed for glucose-stimulated insulin secretion (GSIS), ATP content, caspase-3/7-and 9 and ROS load. This environmental toxic compound impaired islet cells quality, GSIS, ATP-and antioxidant capacity, proving sensitivity of pancreatic islets to AFs (moreso to AFB1), thereby clarifying the possible underlying mechanisms of AFs in endocrine disorders, primarily type-2 diabetes.
真菌毒素，特别是致癌性黄曲霉毒素b1和m1，是食物链中常见的污染物，对暴露的宿主有害。我们分析了自然存在的afb1和afm1水平对不同健康大鼠胰岛的影响，并分别暴露于10-20 ng /mL的afb1和afm1 24和48小时。分析暴露的胰岛葡萄糖刺激胰岛素分泌(GSIS)、ATP含量、caspase-3/7和9以及ROS负荷。这种环境毒性化合物损害了胰岛细胞的质量、GSIS、atp和抗氧化能力，证明了胰岛对AFs(尤其是对AFB1)的敏感性，从而阐明了AFs在内分泌紊乱(主要是2型糖尿病)中的可能潜在机制。
期刊介绍：
Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.
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