Comparing the fibrosis inhibition effect of bevacizumab, 5-fluorouracil, and mitomycin C in trabeculectomy in dogs with glaucoma: A series of six cases

IF 0.2 4区农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE Revista Colombiana De Ciencias Pecuarias Pub Date : 2022-09-28 DOI:10.17533/udea.rccp.v36n2a6

S. Acevedo, N. M. C. Correa Valencia

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Abstract

Anamnesis: A descriptive series of six cases in dogs with glaucoma are presented, aiming to 26 compare the fibrosis inhibition effect of three pharmacological principles applied during 27 trabeculectomy. Clinical findings: The patients obtained a diagnosis of primary chronic 28 closed-angle glaucoma, refractory to topical medical treatment, with no pupillary light reflex, 29 a negative visual threat eyeblink response, and ocular pain. Therapeutic approach: Two 30 patients received an intraoperative application of bevacizumab, two received 5-fluorouracil, 31 and two, mitomycin C. The intraocular pressure (IOP) and the filtering ampoule were observed 32 on days 1, 7, 30, 60, and 90 of postsurgical evolution. Conclusion: According to our results, 33 the bevacizumab manages to regulate the IOP under 25 mmHg and constitutes the drug of 34 potential choice in dogs with primary closed-angle glaucoma, without a previous positive 35 response to topical therapy and subjected to TEC, when compared with 5-fluorouracil and 36 MMC regarding the inhibition effects of fibrosis. 37

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比较贝伐单抗、5-氟尿嘧啶和丝裂霉素C在青光眼犬小梁切除术中的纤维化抑制作用:6例

回顾：本文介绍了6例青光眼犬的描述性系列病例，旨在比较小梁切除术中应用的三种药理学原理对纤维化的抑制作用。临床发现：患者被诊断为原发性慢性闭角型青光眼，对局部药物治疗难治，无瞳孔光反射，29有负面视觉威胁眨眼反应和眼部疼痛。治疗方法：两名30名患者在术中应用贝伐单抗，两名接受5-氟尿嘧啶，31名和两名接受丝裂霉素C。在术后第1、7、30、60和90天观察眼压（IOP）和过滤安瓿32。结论：根据我们的研究结果，33与5-氟尿嘧啶和36MMC相比，贝伐单抗能够将眼压调节在25mmHg以下，是34只原发性闭角型青光眼犬的潜在选择药物，之前对局部治疗和TEC没有阳性反应。37

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来源期刊

Revista Colombiana De Ciencias Pecuarias AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

0.80

自引率

0.00%

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审稿时长

6-12 weeks

期刊介绍： The editors of Revista Colombiana de Ciencias Pecuarias (RCCP) welcome the submission of original manuscripts on experimental and clinical studies associated with the broad areas of animal sciences and veterinary medicine as they interface with biochemistry, molecular biology, physiology, pharmacology, toxicology, pathology, microbiology, parasitology, immunology and epidemiology. The scope of the journal includes studies of basic and applied research in animal management and production, feeding and nutrition, reproduction, breeding, genetics, animal welfare and behavior; as well as animal production focussed from biotechnology, soil science, agrostology, silvopastoral systems, livestock economics and the environment. The criteria for acceptance of papers submitted for publication are originality, quality and clarity of the content. Each contribution must be based on original, unpublished research that has not been simultaneously submitted to other journals. All papers will be peer reviewed. All authors bear responsibility for ensuring the integrity and quality of their reported research. It is the author''s responsibility to secure permission to use figures or tables that have been published elsewhere. Contributions may be classified as original research, review, rapid communication, clinical case studies or methodological articles, as well as news/commentaries or letters to the editor. Most review articles are invited by the editor. Authors interested in submitting a review article should contact the corresponding editor. Rapid publication of original manuscripts is a goal of the journal. Manuscripts must be written in English. Each manuscript is considered for publication with the understanding that it has not been simultaneously submitted to any other journal. Upon acceptance for publication, papers are subject to editorial review and revision.