The value of SOX10 expression in predicting perineural invasion in gastric cancer

Q4 Medicine Revista Espanola de Patologia Pub Date : 2023-10-01 DOI:10.1016/j.patol.2023.05.003

Seyed Amir Miratashi Yazdi , Atieh Moghtadaie , Elham Nazar

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Abstract

Background

SRY-related HMG-box 10 (SOX10) protein has a confirmed role in the regulation of neural cell proliferation and differentiation. It is now suggested that the changes in SOX10 expression may be linked to neural invasion by cancer cells. We aimed to assess the value of SOX10 expression in predicting perineural invasion in gastric cancer.

Methods

A cross-sectional study was performed on 40 patients with gastric cancer. To assess perineural invasion, Hematoxylin & Eosin stained slides were examined. The expression of SOX10 was also examined by immunohistochemistry.

Results

Our study showed higher perineural invasion in those with SOX10 positivity as compared to those without SOX10 expression (64.0% vs. 6.7%, p = 0.001). No association was revealed between other baseline variables and SOX10 positivity. The expression of this marker increased the chance of neural invasion up to 17 times as indicated by the multivariable regression modeling. Multivariable regression modeling indicated that the chance of neural invasion increased up to 17 times in cases of SOX10 positivity.

Conclusion

Overexpression of SOX10 is closely associated with the risk of perineural invasion in gastric cancer.

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SOX10表达在预测胃癌神经周围浸润中的价值

背景：SRY相关的HMG-box 10（SOX10）蛋白已被证实在调节神经细胞增殖和分化中发挥作用。目前认为SOX10表达的变化可能与癌症细胞的神经侵袭有关。我们的目的是评估SOX10表达在预测癌症神经周侵袭中的价值。方法：对40例癌症患者进行横断面研究。为了评估神经侵袭，检查苏木精和曙红染色的玻片。SOX10的表达也通过免疫组织化学检测。结果：我们的研究显示，与未表达SOX10的患者相比，SOX10阳性患者的神经侵袭性更高（64.0%对6.7%，p=0.001）。其他基线变量与SOX10阴性之间没有关联。如多变量回归模型所示，该标志物的表达使神经侵袭的机会增加了17倍。多元回归模型表明，SOX10阳性病例的神经侵袭几率增加了17倍。结论：SOX10的过度表达与癌症神经周侵犯的危险性密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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