K. Benrazzouk, Mehdi Ait Laaradia, Malika Ait Sidi Brahim, S. Ouhaddou, A. Ouhammou, A. Chait, K. Bekkouche, M. Markouk, M. Larhsini
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引用次数: 2
Abstract
Abstract The antivenom property of the methanolic extract of aerial parts of Adenocarpus anagyrifolius against Hottentotta gentili was evaluated by gavage (100, 150, and 200 mg/kg) after subcutaneous injection of LD99 of H. gentili venom. The results showed a very efficient response with a survival of the mice even after 24 h, while the injection with LD50 and a dose of 200 mg/kg showed a restoration of the lesions in different tissues and a significant decrease of the biochemical markers. The high antioxidant efficiency with the presence of active metabolites may explain the potential of A. anagyrifolius as natural product drug candidate.
期刊介绍：
Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.
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