Choosing among unproven therapies for the treatment of life-threatening covid-19 infection: a clinician’s opinion from the beside

R. Raschke
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引用次数: 1

Abstract

We are clearly in unprecedented times. As clinicians watch patients die from COVID-19 infection in the ICU, many feel they cannot wait for clinical trials to prove that various proposed therapies are efficacious. Treatments for which any rationale suggest the possibility of benefit are being administered to patients and the literature abounds with reports of case series or poorly-designed observational trials in which small numbers of patients seem to have favorable outcomes when given these unproven therapies (1). In many cases, these reports are made globally available via social networking without the benefit of peer-review or are being published despite severe methodological flaws that would not have been acceptable prior to the COVID-19 outbreak.
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选择未经证实的治疗危及生命的新冠肺炎感染的疗法:一位临床医生的观点
我们显然处在前所未有的时代。当临床医生看着患者在ICU中死于COVID-19感染时,许多人觉得他们不能等待临床试验来证明各种拟议的治疗方法是有效的。任何理由都表明可能有益的治疗方法都被用于患者,文献中大量的病例系列报告或设计不良的观察性试验,其中少数患者在给予这些未经证实的治疗方法时似乎有良好的结果(1)。这些报告是在没有同行评议的情况下通过社交网络在全球范围内提供的,或者是在方法上存在严重缺陷的情况下发表的,这在COVID-19疫情爆发之前是不可接受的。
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