Insights into the Regulatory Roles of E3 Ubiquitin Ligases Associated with VHL-HIF Axis in Clear Cell Renal Cell Carcinoma

IF 1.8 Q3 UROLOGY & NEPHROLOGY Advances in Urology Pub Date : 2019-09-26 DOI:10.1155/2019/2967183
Wuping Yang, Zhi Li, B. Hong, Y. Gong, K. Gong
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Abstract

Renal cell carcinoma (RCC) accounts for up to 85% to 90% of all kidney cancers. Clear cell RCC (ccRCC), the major subtype of RCC, is mainly characterized by the inactivation of the tumor suppressor gene VHL. pVHL as an E3 ubiquitin ligase targets the hydroxylated form of HIF-α for proteasomal degradation. The loss of VHL function leads to HIF-α aggregation as the main mechanism of ccRCC. Recently, the regulations of ccRCC through other E3 ubiquitin ligases are emerging. Moreover, most of them are associated with the VHL-HIF axis. In this review, we mainly focus on seven E3 ubiquitin ligases JADE1, SIAH1, CHIP, FBXW7, MDM2, SPOP, and HAF. Based on reported researches of these ligases on ccRCC, they are divided into two groups: JADE1, SIAH1, CHIP, and FBXW7 that negatively regulate the growth of ccRCC; MDM2, SPOP, and HAF that promote ccRCC progression. In addition, we further verify these possible links between these E3 ligases and VHL-HIF axis in ccRCC based on The Cancer Genome Atlas RNA-seq and Clinical data. Understanding the mechanisms by which these ligases regulate ccRCC, especially the interplay between these ligases and VHL-HIF axis may enable the development of novel therapeutic approaches for ccRCC. Overall, the present review reveals the potential mechanism by which seven ligases (JADE1, SIAH1, CHIP, FBXW7, MDM2, SPOP, and HAF) regulate ccRCC progression in detail, especially their relationship to VHL-HIF axis.
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与VHL-HIF轴相关的E3泛素连接酶在透明细胞肾细胞癌中的调节作用
肾细胞癌(RCC)占所有肾癌的85%至90%。透明细胞RCC (Clear cell RCC, ccRCC)是RCC的主要亚型,其主要特征是肿瘤抑制基因VHL失活。pVHL作为E3泛素连接酶靶向HIF-α的羟基化形式进行蛋白酶体降解。VHL功能丧失导致HIF-α聚集是ccRCC的主要机制。近年来,通过其他E3泛素连接酶调控ccRCC的研究不断出现。此外,它们大多与VHL-HIF轴有关。本文主要综述了7种E3泛素连接酶JADE1、SIAH1、CHIP、FBXW7、MDM2、SPOP和HAF。根据已报道的ccRCC连接酶的研究,将其分为两组:JADE1、SIAH1、CHIP和FBXW7,它们负调控ccRCC的生长;MDM2、SPOP和HAF促进ccRCC进展。此外,我们基于The Cancer Genome Atlas RNA-seq和临床数据进一步验证了这些E3连接酶与ccRCC中VHL-HIF轴之间的可能联系。了解这些连接酶调节ccRCC的机制,特别是这些连接酶与VHL-HIF轴之间的相互作用,可能有助于开发新的ccRCC治疗方法。总之,本综述揭示了7种连接酶(JADE1、SIAH1、CHIP、FBXW7、MDM2、SPOP和HAF)详细调控ccRCC进展的潜在机制,特别是它们与VHL-HIF轴的关系。
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来源期刊
Advances in Urology
Advances in Urology UROLOGY & NEPHROLOGY-
CiteScore
2.90
自引率
0.00%
发文量
17
审稿时长
15 weeks
期刊介绍: Advances in Urology is a peer-reviewed, open access journal that publishes state-of-the-art reviews and original research papers of wide interest in all fields of urology. The journal strives to provide publication of important manuscripts to the widest possible audience worldwide, without the constraints of expensive, hard-to-access, traditional bound journals. Advances in Urology is designed to improve publication access of both well-established urologic scientists and less well-established writers, by allowing interested scientists worldwide to participate fully.
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