N. Aminudin, Nurul Aqilah Amran, Zaima Azira Zainal Abidin, D. Susanti
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引用次数: 2
Abstract
Abstract Curcumin has been widely acclaimed for several pharmacological properties, such as antioxidant, antimicrobial, anticancer, and anti-inflammation. Curcumin’s poor aqueous solubility, bioavailability, and cellular uptake hamper its ability to display maximum pharmacological effect in the human body. Synthesis of curcumin analogues to enhance its properties can be achieved through biotransformation. Greener, simpler, and higher selectivity and specificity make biotransformation an alternative approach when preparing curcumin analogues for the structure–activity relationship (SAR) study intended for drug design. This work systematically reviews the biotransformation of curcumin by utilizing fungi, gut microbiota, and enzymes. The SAR study of curcumin and its analogues for several bioactivities is also highlighted. Graphical Abstract
期刊介绍：
Biocatalysis and Biotransformation publishes high quality research on the application of biological catalysts for the synthesis, interconversion or degradation of chemical species.
Papers are published in the areas of:
Mechanistic principles
Kinetics and thermodynamics of biocatalytic processes
Chemical or genetic modification of biocatalysts
Developments in biocatalyst''s immobilization
Activity and stability of biocatalysts in non-aqueous and multi-phasic environments, including the design of large scale biocatalytic processes
Biomimetic systems
Environmental applications of biocatalysis
Metabolic engineering
Types of articles published are; full-length original research articles, reviews, short communications on the application of biotransformations, and preliminary reports of novel catalytic activities.
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