Quantification of Neutrophil Extracellular Traps (NETs) in Pediatric Patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through Plasma and Peripheral Smear Analysis
Rachelle Thompson, Megan Zoltowski, Derick Lim, C. Diorio, Elizabeth M Margolskee, M. Paessler, Veronica Bochenek, E. Behrens, D. Teachey, H. Bassiri, Michele P. Lambert, K. Gollomp
{"title":"Quantification of Neutrophil Extracellular Traps (NETs) in Pediatric Patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through Plasma and Peripheral Smear Analysis","authors":"Rachelle Thompson, Megan Zoltowski, Derick Lim, C. Diorio, Elizabeth M Margolskee, M. Paessler, Veronica Bochenek, E. Behrens, D. Teachey, H. Bassiri, Michele P. Lambert, K. Gollomp","doi":"10.1182/blood-2022-170932","DOIUrl":null,"url":null,"abstract":"Background: In response to in fl ammation, neutrophils expel NETs, decondensed chromatin coated with histones and granular proteins that capture pathogens. NET degradation products (NDPs), including cell free (cf) DNA, citrullinated histone 3 (citH3), and myeloperoxidase (MPO), are elevated in adults with COVID-19 MIS-C. Correlation of and citH3 with proteins associated with neutrophil","PeriodicalId":9102,"journal":{"name":"Blood","volume":"140 1","pages":"5481 - 5482"},"PeriodicalIF":23.1000,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1182/blood-2022-170932","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Background: In response to in fl ammation, neutrophils expel NETs, decondensed chromatin coated with histones and granular proteins that capture pathogens. NET degradation products (NDPs), including cell free (cf) DNA, citrullinated histone 3 (citH3), and myeloperoxidase (MPO), are elevated in adults with COVID-19 MIS-C. Correlation of and citH3 with proteins associated with neutrophil
期刊介绍：
Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
