Monocationic Chlorin Photosensitizer for Efficient Photoinactivation of Antibiotic-Resistant Gram-Negative Microorganisms

Abstract

A water-soluble monocationic chlorin photosensitizer for antimicrobial photodynamic therapy of superficial localized infections has been proposed. The antimicrobial activity of this compound against planktonic forms of nosocomial antibiotic-resistant gram-negative pathogens, Pseudomonas aeruginosa, Enterobacter cloacae, and Acinetobacter baumannii, has been studied in comparison with the activity of the photosensitizer Fotoran e₆, widely used in the clinical photodynamic therapy of tumors. It has been shown that both photosensitizers possess low dark toxicity; however, the light toxicity of the monocationic chlorin is higher by several orders of magnitude, and it can be proposed as a new agent for the antimicrobial photodynamic therapy.