Metabolic reprogramming and cancer precision medicine: a narrative review

Abstract

Precision medicine in cancer aims to improve outcome of cancer patients by using customized strategy to prevent, diagnose and treat cancer according to tumor molecular features. As the metabolic reprogramming empowers cancer cells flexibility to adapt stress and microenvironment, metabolic reprogramming is critical for tumorigenesis, cancer progression, tumor responses upon treatment, and therapy resistance. Therefore, targeting cancer metabolism can provide effective approaches for cancer precision management. Increasing research in cancer metabolism investigate how reprogrammed metabolism works and drives rapid cell proliferation, or which reprogrammed activities are relevant to resistance of treatment. Deep understanding of these molecular insights about cancer metabolism is the foundation for design of effective cancer management and therapeutic strategies for different cancer Review Article