Efficacy of Hyaluronic Acid Injections in the Treatment of Osteoarthritis of the Knee

Erica Trimm
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Abstract

Background: Hyaluronic acid injections for treatment of osteoarthritis of the knee are a widely used yet highly controversial therapy. Many societal guidelines recommend against the use of such injections. Objective: This review aims to investigate efficacy of intra-articular hyaluronic acid injections for treatment of osteoarthritis of the knee. Conclusion: There are many factors impacting the efficacy of intra-articular hyaluronic acid injections. This can include source of hyaluronic acid, dosing regimen, molecular weight of the product, and patient characteristics. Overall, hyaluronic acid injections can be effective in reducing pain and improving physical function in patients with osteoarthritis of the knee. These injections may also prolong time between diagnosis and arthroplasty. Adverse events after injection are rare and can be product-related. Radiologic findings and severity of disease can be predictive of successful treatment outcomes. More consistent research will be necessary to overturn societal guideline recommendations to support treatment with intra-articular hyaluronic acid products.
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透明质酸注射治疗膝关节骨性关节炎的疗效观察
背景:透明质酸注射治疗膝关节骨性关节炎是一种应用广泛但极具争议的治疗方法。许多社会指导方针建议不要使用这种注射。目的:探讨关节内注射透明质酸治疗膝关节骨性关节炎的疗效。结论:影响关节内注射透明质酸疗效的因素很多。这可能包括透明质酸的来源、给药方案、产品的分子量和患者特征。总的来说,透明质酸注射可以有效地减轻膝盖骨关节炎患者的疼痛和改善身体功能。这些注射也可能延长诊断和关节成形术之间的时间。注射后的不良事件非常罕见,可能与产品有关。放射学检查结果和疾病的严重程度可以预测成功的治疗结果。有必要进行更一致的研究,以推翻支持关节内透明质酸产品治疗的社会指南建议。
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