Hepatocellular Liver Function of Immunosuppressed Rats with Oral Candidiasis after Hyperbaric Oxygen Treatment: Alanine Transaminase and Aspartate Transaminase Levels

IF 0.1 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Archives of Orofacial Science Pub Date : 2021-09-22 DOI:10.21315/aos2021.16.s1.2
A. F. Pargaputri, D. Andriani
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引用次数: 1

Abstract

Hepatocellular utility is observed by measuring the hepatocellular enzymes. Changes in its serum levels are related to liver dysfunction. Liver is one of the immunoprotective organs. Continuous use of immunosuppressive drugs can cause oral candidiasis and give effects to liver function. Hyperbaric oxygen treatment (HBOT), while reducing fungal infections, can also repair the liver function. The aim of this study was to investigate the alanine transaminase (ALT) and aspartate transaminase (AST) levels of immunosuppressed rats with oral candidiasis treated with hyperbaric oxygen. Twelve Wistar rats were divided into three groups: K− (normal/ healthy), K+ (oral candidiasis immunosuppressed rats), and P (oral candidiasis immunosuppressed rats treated hyperbaric oxygen). K+ and P groups were immunosuppressed by giving dexamethasone 0.5 mg/day/rat orally for 14 days, added with tetracycline 1 mg/day/rat. HBOT was given in five days successively. Blood serum of rats in all groups were taken to calculate the ALT and AST levels. ALT and AST levels in K+ showed higher value than K− and P groups. The data were analysed with one-way ANOVA test and showed significant difference in ALT levels (p < 0.05), while in AST levels there was no significant difference among the groups (p > 0.05). This study showed that HBOT affected the ALT and AST levels of immunosuppressed rats with oral candidiasis.
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高压氧治疗后免疫抑制口腔念珠菌病大鼠肝细胞肝功能:丙氨酸转氨酶和天冬氨酸转氨酶水平
通过测量肝细胞酶来观察肝细胞的效用。其血清水平的变化与肝功能障碍有关。肝脏是免疫保护器官之一。持续使用免疫抑制药物会导致口腔念珠菌感染并影响肝功能。高压氧治疗(HBOT)在减少真菌感染的同时,也可以修复肝功能。本研究的目的是研究高压氧治疗免疫抑制的口腔念珠菌感染大鼠的丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)水平。12只Wistar大鼠分为三组:K-(正常/健康)、K+(口腔念珠菌免疫抑制大鼠)和P(高压氧治疗的口腔念珠菌免疫抑制剂大鼠)。K+和P组通过给予地塞米松0.5mg/天/大鼠口服14天,并添加四环素1mg/天/大白鼠来抑制免疫抑制。连续5天给予HBOT。取各组大鼠血清,计算ALT和AST水平。K+组的ALT和AST水平高于K−和P组。结果表明,HBOT对免疫抑制的口腔念珠菌感染大鼠的ALT和AST水平有显著影响。
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来源期刊
Archives of Orofacial Science
Archives of Orofacial Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
0.30
自引率
50.00%
发文量
27
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