An Observational Study on the Intraoperative Awareness Following General Anesthetic Drugs

IF 0.4 Q4 PHARMACOLOGY & PHARMACY Journal of Pharmacology & Pharmacotherapeutics Pub Date : 2023-03-01 DOI:10.1177/0976500X231172579
S. Priyadharsini K., Nikita Haldar, K. Prasad T, Mali Kalpana Ramanna, Maduram Annamalai
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Abstract

Objective To determine intraoperative awareness and estimate the factors associated with intraoperative awareness. Methods An observational cross-sectional study was carried out after approval from the institutional ethical committee. The duration of the study is 2 months. After completion of the surgical procedure, anesthesia was reversed, and there was an adequate return of consciousness. The patients were interviewed about their surgery using the modified form of the Brice questionnaire. After the questionnaire was completed, it was analyzed, and patients were categorized into either having definite awareness, possible awareness, or no awareness. Results It was observed that out of 90 patients operated on under general anesthesia, eight reported having remembered something under general anesthesia. Out of eight patients, two were found to have definite awareness, and the occurrence of definite awareness was calculated to be 2.22%. Six patients were categorized under possible awareness, and the occurrence of possible awareness was estimated to be 6.6% in our study. Conclusion The occurrence of intraoperative awareness was estimated to be 8.8%, including definite and possible awareness under general anesthesia. Finally, we conclude that intraoperative awareness might be due to the inadequate depth of general anesthesia given to the patients. The dose of general anesthetic drugs was not maintained based on its minimum alveolar concentration (MAC).
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全麻用药后术中意识的观察研究
目的确定术中意识,并估计与术中意识相关的因素。方法经机构伦理委员会批准后进行横断面观察研究。研究持续时间为2个月。手术结束后,麻醉被逆转,意识得到充分恢复。使用改良的Brice问卷形式对患者进行了关于手术的访谈。问卷完成后,对其进行分析,并将患者分为有明确意识、可能意识或无意识。结果在90例全麻下手术的患者中,有8例报告在全麻下记得一些东西。在8名患者中,有2名患者被发现有明确的意识,明确意识的发生率为2.22%。6名患者被归类为可能意识,在我们的研究中,可能意识的出现率估计为6.6%。结论术中意识的发生率估计为8.8%,包括全麻下的明确意识和可能意识。最后,我们得出结论,术中意识可能是由于患者全身麻醉深度不足。全身麻醉药物的剂量没有根据其最小肺泡浓度(MAC)来维持。
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37
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