A randomized controlled trial to compare the effect of ultrasound-guided, single-dose platelet-rich plasma and corticosteroid injection in patients with carpal tunnel syndrome

Reni Benny, S. Venkataraman, A. Chanu, U. Singh, D. Kandasamy, Raghavendra Lingaiah
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Abstract

Background: Platelet-rich plasma (PRP) may aid functional recovery in compressive neuropathies. Objective: To compare the effect of autologous PRP with corticosteroid injection in patients with refractory carpal tunnel syndrome (CTS). Materials and Methods: This was a randomized controlled trial on 84 adults, who received either single-dose, ultrasound-guided PRP or corticosteroid. Boston Carpal Tunnel Questionnaire and cross-sectional area of median nerve were assessed at 0, 4, and 12 weeks. Results: A statistically significant 54.76% improvement (P < 0.05) in functional status was observed in both the groups at 12 weeks. Conclusion: PRP is as effective as corticosteroids in relieving pain and improving function in CTS.
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一项比较超声引导下单剂量富血小板血浆和皮质类固醇注射对腕管综合征患者疗效的随机对照试验
背景:富含血小板的血浆(PRP)可能有助于压迫性神经病的功能恢复。目的:比较自体PRP与皮质类固醇注射治疗难治性腕管综合征(CTS)的疗效。材料和方法:这是一项针对84名成年人的随机对照试验,他们接受了单剂量、超声引导的PRP或皮质类固醇治疗。在0、4和12周时评估波士顿腕管问卷和正中神经横截面积。结果:在12周时,两组的功能状态都有54.76%的改善(P<0.05),具有统计学意义。结论:PRP与皮质类固醇激素一样能有效缓解CTS患者的疼痛,改善CTS患者的功能。
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