Possibilities of spectrometric diagnostics of benign and malignant conjunctival tumors

S. Saakyan, D. A. Skladnev, A. P. Alekseeva, V. Sorokin, O. Beznos
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Abstract

Purpose: to compare the regenerative activity of benign and malignant conjunctival tumors.Material and methods. The study was performed on 86 tumor biopsies from patients with a clinically diagnosed conjunctival neoplasm. Healthy tissues from the same eye were taken as a control sample. The optical density of the reaction mixture containing biogenic nanoparticles formed in the presence of conjunctival tumors and the corresponding paired healthy tissue samples from the control group was measured by spectrophotometry. The data obtained were later verified by a pathohistological analysis.Results. A significantly higher level of in situ formation of biogenic silver nanoparticles was recorded in the reaction mixture with malignant tumors of the conjunctiva (3.0 ± 1.1, (n = 32) compared to benign tumors (1.3 ± 0.2, n = 54). No differences were found between various types of benign tumors. In samples of malignant tumors, the indicators of recovery activity in melanoma (3.4 ± 1.0, n = 14) and lymphoma (2.8 ± 1.0, n = 7) were significantly higher than in squamous cell carcinoma (2.0 ± 0.6, n = 11), but no significant differences were found between the two types of tumors.Conclusion. The method of spectrophotometric measurement of the regenerative activity of conjunctival tumors can be used in preoperative or intraoperative diagnostics thanks to the fact that the results can be obtained rapidly, which will help to quickly determine the extent of surgical intervention needed and optimize the treatment tactics.
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光谱法诊断结膜良恶性肿瘤的可能性
目的:比较良性和恶性结膜肿瘤的再生活性。材料和方法。这项研究对86例临床诊断为结膜肿瘤的患者进行了肿瘤活检。取同一只眼睛的健康组织作为对照样品。通过分光光度法测量含有在结膜肿瘤存在下形成的生物纳米颗粒的反应混合物和来自对照组的相应配对健康组织样品的光密度。所获得的数据随后通过病理学分析进行了验证。后果与良性肿瘤(1.3±0.2,n=54)相比,在结膜恶性肿瘤的反应混合物中,生物银纳米颗粒的原位形成水平显著更高(3.0±1.1,(n=32)。不同类型的良性肿瘤之间没有发现差异。在恶性肿瘤样本中,黑色素瘤(3.4±1.0,n=14)和淋巴瘤(2.8±1.0,n=7)的恢复活性指标显著高于鳞状细胞癌(2.0±0.6,n=11),但两种类型的肿瘤之间没有显著差异。结论结膜肿瘤再生活性的分光光度测量方法可用于术前或术中诊断,因为可以快速获得结果,这将有助于快速确定所需手术干预的程度并优化治疗策略。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
107
审稿时长
16 weeks
期刊最新文献
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