The Functional Adaptability of Hyporesponsive T Cells and its Impact on Transplant Outcomes.

IF 1.6 Q2 SURGERY Current Transplantation Reports Pub Date : 2023-09-01 Epub Date: 2023-05-31 DOI:10.1007/s40472-023-00398-1

Dawei Zou, Xiaolong Zhang, Wenhao Chen

{"title":"The Functional Adaptability of Hyporesponsive T Cells and its Impact on Transplant Outcomes.","authors":"Dawei Zou, Xiaolong Zhang, Wenhao Chen","doi":"10.1007/s40472-023-00398-1","DOIUrl":null,"url":null,"abstract":"Purpose of review: The functional adaptability of hyporesponsive T cells in precluding transplant acceptance is not well recognized. This review aims to highlight the impact of this mechanism on transplant outcomes and explore potential strategies to overcome this challenge.Recent findings: Hyporesponsive T cells exist in two major distinct states: anergy and exhaustion. In response to infection, alloreactive anergic T cells can differentiate into IFN-γ producing effector cells, leading to the abrogation of transplant acceptance. Depleting anergic T cells has been shown to promote transplant acceptance under infection. In addition, \"precursor exhausted\" T (TPEX) cells can differentiate into effector cells during checkpoint inhibitor immunotherapy. This helps explain why using checkpoint inhibitors in transplant recipients heightens the risk of graft rejection.Summary: This review focuses on the functional adaptability of hyporesponsive T cells and highlights the importance of further investigations into strategies to disarm these cells. Such research could have significant clinical implications for transplant patients.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"147-152"},"PeriodicalIF":1.6000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363493/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Transplantation Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40472-023-00398-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: The functional adaptability of hyporesponsive T cells in precluding transplant acceptance is not well recognized. This review aims to highlight the impact of this mechanism on transplant outcomes and explore potential strategies to overcome this challenge.

Recent findings: Hyporesponsive T cells exist in two major distinct states: anergy and exhaustion. In response to infection, alloreactive anergic T cells can differentiate into IFN-γ producing effector cells, leading to the abrogation of transplant acceptance. Depleting anergic T cells has been shown to promote transplant acceptance under infection. In addition, "precursor exhausted" T (T_PEX) cells can differentiate into effector cells during checkpoint inhibitor immunotherapy. This helps explain why using checkpoint inhibitors in transplant recipients heightens the risk of graft rejection.

Summary: This review focuses on the functional adaptability of hyporesponsive T cells and highlights the importance of further investigations into strategies to disarm these cells. Such research could have significant clinical implications for transplant patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

低反应性T细胞的功能适应性及其对移植结果的影响

综述目的：低反应性T细胞在阻止移植接受中的功能适应性尚未得到很好的认识。这篇综述旨在强调这一机制对移植结果的影响，并探讨克服这一挑战的潜在策略。最近发现：低反应性T细胞存在两种主要的不同状态：能量和衰竭。在对感染的反应中，同种异体反应性无能T细胞可以分化为产生IFN-γ的效应细胞，从而导致移植接受的取消。耗尽无能T细胞已被证明可促进感染下的移植接受。此外，在检查点抑制剂免疫治疗过程中，“前体耗竭”T细胞（TPEX）可以分化为效应细胞。这有助于解释为什么在移植受者中使用检查点抑制剂会增加移植排斥的风险。摘要：本文综述了低反应性T细胞的功能适应性，并强调了进一步研究解除这些细胞的策略的重要性。这样的研究可能对移植患者有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Transplantation Reports Medicine-Surgery

CiteScore

3.40

自引率

4.80%

发文量

期刊介绍： Under the guidance of Dr. Dorry Segev, from Johns Hopkins, Current Transplantation Reports will provide an in-depth review of topics covering kidney, liver, and pancreatic transplantation in addition to immunology and composite allografts.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of transplantation.