Oxidative Stress and Dyslipidemia as Indicators of Pathogenesis of Preeclampsia in Pregnant Sudanese Women

Abstract

Background/purpose: Pre-eclampsia contributes remarkably to maternal, fetal, and neonatal morbidity and mortality. Hyperlipidemia in preeclampsia has been studied in relation to several factors. The objective of this study was to determine the role of oxidative stress and dyslipidemia as indicators in the pathogenesis of preeclampsia. Patients and methods: This was a cross-sectional (case-control) study conducted to evaluate the role of oxidative stress and dyslipidemia as indicators of pathogenesis and risks of preeclampsia in pregnant Sudanese women attending Wad- Medani Obstetrics and Gynecology Teaching Hospital. Result and conclusion: pregnant with an increase in BMI have a higher chance of developing PE. Low level of high-density lipoprotein cholesterol and high level of low-density lipoprotein cholesterol define that dyslipidemia increasing the risk of PE. Decreased levels of NO and TAC might reflect the oxidative stress and likely contribute to the pathophysiological mechanisms of PE.