Supplemental mineral ions for bone regeneration and osteoporosis treatment

Q1 Medicine Engineered regeneration Pub Date : 2023-06-01 DOI:10.1016/j.engreg.2023.02.003

Yingchao Su , Matthew Cappock , Stephanie Dobres , Allan J. Kucine , Wayne C. Waltzer , Donghui Zhu

{"title":"Supplemental mineral ions for bone regeneration and osteoporosis treatment","authors":"Yingchao Su , Matthew Cappock , Stephanie Dobres , Allan J. Kucine , Wayne C. Waltzer , Donghui Zhu","doi":"10.1016/j.engreg.2023.02.003","DOIUrl":null,"url":null,"abstract":"<div><p>Mineral ions play a crucial role in various biological processes in the human body, particularly in bone repair and regeneration. Supplementation with mineral ions offers several advantages over other therapies or treatments for bone repair and regeneration, such as higher biosafety, universal applicability, and compatibility with the immune system. Additionally, supplementation with mineral ions may avoid the need for invasive surgical procedures. The aim of this review is to provide a comprehensive overview of the functions of potentially beneficial mineral ions and their effects on bone regeneration and osteoporosis treatment. By examining previous studies, including in vitro cellular experiments, in vivo animal models, and clinical trials, this review compares the benefits and potential adverse effects of these mineral ions. Moreover, the review provides guidelines for suggested daily supplementation of these mineral ions to assist future preclinical and clinical studies in bone regeneration and osteoporosis treatment.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"4 2","pages":"Pages 170-182"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineered regeneration","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666138123000142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 6

Abstract

Mineral ions play a crucial role in various biological processes in the human body, particularly in bone repair and regeneration. Supplementation with mineral ions offers several advantages over other therapies or treatments for bone repair and regeneration, such as higher biosafety, universal applicability, and compatibility with the immune system. Additionally, supplementation with mineral ions may avoid the need for invasive surgical procedures. The aim of this review is to provide a comprehensive overview of the functions of potentially beneficial mineral ions and their effects on bone regeneration and osteoporosis treatment. By examining previous studies, including in vitro cellular experiments, in vivo animal models, and clinical trials, this review compares the benefits and potential adverse effects of these mineral ions. Moreover, the review provides guidelines for suggested daily supplementation of these mineral ions to assist future preclinical and clinical studies in bone regeneration and osteoporosis treatment.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

补充矿物质离子用于骨再生和骨质疏松症治疗

矿物离子在人体的各种生物过程中发挥着至关重要的作用，尤其是在骨骼修复和再生中。与骨修复和再生的其他疗法或治疗方法相比，补充矿物离子具有几个优势，如更高的生物安全性、普遍适用性和与免疫系统的兼容性。此外，补充矿物离子可以避免侵入性外科手术的需要。这篇综述的目的是全面概述潜在有益矿物离子的功能及其对骨再生和骨质疏松症治疗的影响。通过检查以前的研究，包括体外细胞实验、体内动物模型和临床试验，这篇综述比较了这些矿物离子的益处和潜在的不良影响。此外，该综述为建议每天补充这些矿物离子提供了指南，以帮助未来在骨再生和骨质疏松症治疗方面的临床前和临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊