Phytochemical Analysis and in vitro Antioxidant Potential of Aqueous and Ethanol Extracts of Irvingia gabonensis Stem Bark

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.039
C. Otitolaiye, A. Omonkhua, K. Oriakhi, E. Okello, I. Onoagbe, F. Okonofua
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引用次数: 1

Abstract

Background: Irvingia gabonensis extracts are documented to possess antidiabetic, hypocholesterolemic, and antioxidant activities. The phytochemical components of medicinal plants are responsible for their therapeutic properties, particularly those with antioxidant properties. Objectives: The quantitative phytochemicals and in vitro antioxidant properties of the aqueous and ethanol extracts of I. gabonensis stem bark were assessed in this study. Materials and Methods: Standard techniques were used to measure the concentrations of phenols, flavonoids, tannins, alkaloids, steroids, and saponins in water and alcohol extracts of this plant. Total Antioxidant Power (TAP) and the extract's capacity to scavenge free radicals including superoxide, nitric oxide, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis-(3-ethylbenzoth iazoline-6-sulfonic acid) (ABTS + ), β-carotene, and hydrogen peroxide were also evaluated. The extracts' Ferric-Reducing Potential (FRAP) was also assessed. Results: The alcohol extract had significantly ( P < 0.05) higher concentrations of all the phytochemicals measured as well as near significantly ( P <0.066) higher TAP in comparison to the aqueous extracts. In general, the in vitro antioxidant capacity of the ethanol extract surpassed that of the water extract. The ethanol extract had IC 50 values that were comparable to or less than the reference standards for its ability to neutralize nitric oxide, H 2 O 2 , superoxide, and DPPH radicals. Conclusion: The outcomes of the quantitative phytochemical analysis and in vitro antioxidant effects of aqueous and ethanol extracts of I. gabonensis stem bark clearly show their potential as an excellent reservoir of bioactive compounds and scavengers of deleterious oxidants; properties that could be explored therapeutically.
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山竹茎皮水提取物和乙醇提取物的植物化学分析及体外抗氧化能力
背景:葛藤提取物被证明具有抗糖尿病、降胆固醇和抗氧化活性。药用植物的植物化学成分对其治疗特性负责,尤其是那些具有抗氧化特性的植物。目的:本研究对山竹茎皮水提取物和乙醇提取物的植物化学成分和体外抗氧化性能进行了定量评价。材料与方法:采用标准技术测定该植物水提物和醇提物中酚类、黄酮类、单宁、生物碱、甾体和皂苷的含量。还评估了提取物的总抗氧化能力(TAP)和清除自由基的能力,包括超氧化物、一氧化氮、2,2-二苯基-1-苦基肼(DPPH)、2,2-锌基双-(3-乙基苯并噻唑啉-6-磺酸)(ABTS+)、β-胡萝卜素和过氧化氢。还评估了提取物的铁还原潜力(FRAP)。结果:与水提取物相比,醇提取物具有显著(P<0.05)高的所有植物化学物质浓度,以及接近显著(P<0.01)高的TAP。总的来说,乙醇提取物的体外抗氧化能力超过了水提取物。乙醇提取物的IC50值与其中和一氧化氮、H2 O2、超氧化物和DPPH自由基的能力相当或低于参考标准。结论:山竹茎皮水提取物和乙醇提取物的定量植物化学分析结果和体外抗氧化作用清楚地表明,它们是生物活性化合物的良好库和有害氧化剂的清除剂;可以在治疗上探索的特性。
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来源期刊
Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
自引率
14.30%
发文量
61
期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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