Evidence of stunting genes in Asian countries: A review

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100970
Wan Rohani Wan Taib, Imilia Ismail
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引用次数: 3

Abstract

Stunting defined as anthropometrically as height-for-age Z-score (HAZ) with less than 2 standard deviation (SD) has been observed more prevalent in children in developing countries that reflect the linear growth failure. It was estimated that the prevalence of stunting in Asian countries ranges from 30% - 69%. Stunting occurs due to the interplay of genetic and environmental factors. The susceptible genes involve in hormone signalling, paracrine factor, matric molecules, intercellular pathways and cellular processes of epiphyseal growth plate. Many genetic studies conducted among stunted children has elucidated the role of genes in affecting the attribute factors such as low birth weight, socio-economy, poor preventive health care and others. Whole genome sequencing revealed potential putative genes which involve in different pathways in related to retarded epiphyseal growth plate in various Asian countries such GHSR, GH1, GHRHR, STAT5B, IGF1, COMP and many more associated genes. The data emphasize that these potential genetic markers may provide better treatment in targeting the related pathophysiology in stunting development. In this current national implementation, genetic testing has not yet been permeated to the clinical practice for a standard evaluation since lack of genetic studies on stunting genes conducted in Asian countries, particularly Malaysia.

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亚洲国家发育迟缓基因的证据:综述
发育迟缓在发展中国家的儿童中更为普遍,在人体测量学上,发育迟缓被定义为年龄身高z分数(HAZ)小于2个标准差(SD),这反映了线性生长衰竭。据估计,亚洲国家的发育迟缓患病率在30%至69%之间。发育迟缓是遗传和环境因素相互作用的结果。易感基因涉及骨骺生长板的激素信号、旁分泌因子、基质分子、细胞间通路和细胞过程。在发育迟缓儿童中进行的许多遗传研究阐明了基因在影响诸如低出生体重、社会经济、不良预防保健和其他属性因素方面的作用。全基因组测序揭示了亚洲各国与骺端生长迟缓相关的可能参与不同途径的基因,如GHSR、GH1、GHRHR、STAT5B、IGF1、COMP等多种相关基因。这些数据强调,这些潜在的遗传标记可能为发育迟缓的相关病理生理提供更好的治疗。在目前的国家实施中,基因检测尚未渗透到临床实践中进行标准评估,因为在亚洲国家,特别是马来西亚,缺乏对发育迟缓基因的遗传研究。
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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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