Relationship Between Advanced Glycation End Products, Coronary Risk Factors, Abdominal Aortic Diameter and Carotid Intimal Thickness in Elderly Diabetics

IF 1 Q4 GERIATRICS & GERONTOLOGY Aging Medicine and Healthcare Pub Date : 2019-09-24 DOI:10.33879/amh.2019.1904

Walaa W Aly, M. M. Monier, Dalia Hussein Helmy El-Sheikh, M. S. Amer, O. Omar, Ramy M Mahmoud

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Abstract

Background/Purpose: Aortic aneurysm early detection is crucial in cases having elevated clinical risk due to its life-threatening sequelae. This study aims to understand the relationship between advanced glycation end products (AGEs), coronary risk factors, abdominal aortic diameter (AAD) and carotid blood flow in elderly diabetes mellitus (DM). Methods: A case control study conducted on 90 elderly patients, 60 years and above, recruited from the Ain Shams University Hospital. Elderly subjects were divided into 3 groups. Group I (controls): 30 patients without DM; Group II (cases): 30 diabetic cases without co-morbidities; and Group III (cases): 30 diabetic cases with co-morbidities. All groups have undergone assessment of blood sugar, serum lipids, and AGEs, in addition to measurement of carotid intima-medial thickness (CIMT) by carotid duplex scan. Results: Coronary risk is significantly high in Group III (19.300±9.542) followed by Group II (18.200±11.704) then the control group (7.562±5.241). CIMT is significantly higher in Group III (1.377±0.220) followed by Group II (1.193±0.276) then the control group (0.993±0.246). AGEs are significantly high in Group I followed by Group II then Group III. CIMT is statistically significantly correlated with AGEs in Group I. No statistically significant correlation between AAD and AGEs in study groups. There is highly significant correlation between coronary risk and AGEs in Group II. Conclusion: Mean carotid intimal thickness is considered as an early marker of atherosclerotic disease. 2663-8851/Copyright © 2019, Asian Association for Frailty and Sarcopenia and Taiwan Association for Integrated Care. Published by Full Universe Integrated Marketing Limited. *Correspondence Dr. Walaa W Aly Geriatric and Gerontology Department, Faculty of Medicine, Ain Shams University, Egypt E-mail: walaawessam@yahoo.com Received 16 February 2019 Accepted 20 June 2019

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老年糖尿病患者晚期糖化终产物、冠状动脉危险因素、腹主动脉直径和颈动脉内膜厚度的关系

背景/目的：对于因其危及生命的后遗症而导致临床风险升高的病例，早期发现主动脉瘤至关重要。本研究旨在了解老年糖尿病患者晚期糖基化终产物（AGEs）、冠状动脉危险因素、腹主动脉直径（AAD）和颈动脉血流量之间的关系。方法：对艾因沙姆斯大学医院招募的90名60岁及以上老年患者进行病例对照研究。将老年受试者分为3组。I组（对照组）：30例无DM患者；第二组（例）：30例无合并症的糖尿病患者；第三组（例）：糖尿病合并症30例。除了通过颈动脉双重扫描测量颈动脉内膜中层厚度（CIMT）外，所有组都接受了血糖、血脂和AGEs的评估。结果：冠状动脉风险在III组（19.300±9.542）、II组（18.200±11.704）和对照组（7.562±5.241。CIMT与I组的AGEs在统计学上显著相关。研究组的AAD与AGEs之间没有统计学上显著的相关性。在II组中，冠状动脉风险与AGEs之间存在高度显著的相关性。结论：平均颈动脉内膜厚度是动脉粥样硬化性疾病的早期标志。2663-8851/版权所有©2019，亚洲虚弱和肉瘤协会和台湾综合护理协会。由Full Universe Integrated Marketing Limited出版*通讯：埃及艾因沙姆斯大学医学院Walaa W Aly老年医学和老年病学系电子邮件：walaawessam@yahoo.com2019年2月16日收到2019年6月20日接受

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来源期刊

Aging Medicine and Healthcare Medicine-Geriatrics and Gerontology

CiteScore

1.60

自引率

20.00%

发文量