{"title":"In situ 3D bioprinting: A promising technique in advanced biofabrication strategies","authors":"Zahra Mahmoudi , Mahsa Sedighi , Arman Jafari , Saman Naghieh , Evan Stefanek , Mohsen Akbari , Houman Savoji","doi":"10.1016/j.bprint.2023.e00260","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>3D bioprinting<span> is a potential technique for developing functional 3D tissues for tissue engineering<span> and regenerative medicine applications. Recently, the direct formation of 3D tissues on </span></span></span>defect sites, known as </span><em>in situ</em> 3D bioprinting, has gained increasing attention to fulfill unmet needs. <em>In situ</em> 3D bioprinting has shown the capability of addressing problems, such as the need for invasive operations for transplantation and fabrication of sophisticated, irregularly shaped constructs, demonstrating its advantages over conventional methods. This review summarizes the two main approaches used for <em>in situ</em> bioprinting, namely robotic and handheld bioprinting. Besides, the latest advances in organ regeneration using this approach are discussed. Furthermore, some natural and synthetic materials used for <em>in situ</em> bioprinting are briefly presented.</p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 5
Abstract
3D bioprinting is a potential technique for developing functional 3D tissues for tissue engineering and regenerative medicine applications. Recently, the direct formation of 3D tissues on defect sites, known as in situ 3D bioprinting, has gained increasing attention to fulfill unmet needs. In situ 3D bioprinting has shown the capability of addressing problems, such as the need for invasive operations for transplantation and fabrication of sophisticated, irregularly shaped constructs, demonstrating its advantages over conventional methods. This review summarizes the two main approaches used for in situ bioprinting, namely robotic and handheld bioprinting. Besides, the latest advances in organ regeneration using this approach are discussed. Furthermore, some natural and synthetic materials used for in situ bioprinting are briefly presented.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.