Acitretin-Induced systemic capillary leak syndrome

Kolluri Siva Bala Vaishnavi, Geetakiran Arakkal, M. Lohita, S. Kodali
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Abstract

Systemic capillary leak syndrome (SCLS) is a potentially life-threatening condition characterized by recurrent episodes of massive plasma sequestration into the interstitial space causing vascular collapse. SCLS is a rare syndrome where only a few cases are published in literature. The etiology being either idiopathic (Clarkson's disease) or secondary to underlying causes such as sepsis and drugs and diagnosis is often missed due to nonspecific presentation. We hereby present a case of pustular psoriasis on acitretin who developed SCLS after increasing the dose and eventually succumbed. Acitretin is considered the drug of choice in extensive psoriasis despite having side effect profiles. Although most of them are dose dependent and not life threatening. This is one of the rare complications where early detection of the condition, withdrawal of the drug, and appropriate management can be lifesaving.
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阿曲素引起的全身毛细血管渗漏综合征
系统性毛细血管渗漏综合征(SCLS)是一种潜在的危及生命的疾病,其特征是反复出现大量血浆滞留到间质间隙导致血管塌陷。SCLS是一种罕见的综合征,只有少数病例发表在文献中。病因要么是特发性的(克拉克森病),要么是继发于败血症和药物等潜在原因,通常由于非特异性表现而错过诊断。我们在此报告一例使用阿曲汀治疗的脓疱性银屑病,在增加剂量后出现SCLS,最终死亡。阿曲汀被认为是治疗广泛性银屑病的首选药物,尽管有副作用。尽管它们大多具有剂量依赖性,不会危及生命。这是一种罕见的并发症,早期发现病情、停药和适当的管理可以挽救生命。
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