Novelty in the development of biodegradable polymer coatings for biomedical devices: paclitaxel grafting on PDMMLA derivatives

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2022-03-20 DOI:10.1080/15685551.2022.2054116
Elnaz Gholizadeh, Meriem Naim, R. Belibel, H. Hlawaty, C. Barbaud
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引用次数: 1

Abstract

ABSTRACT Biocompatible and biodegradable polymers are widely used in the medical field. In some cases, the biopolymer is accompanied by an active drug, which is delivered locally in a controlled manner in order to improve the healing conditions. Poly([R,S]-3,3-dimethylmalic acid) (PDMMLA) is a synthetic amphiphilic biodegradable polymer, which unlike PLA, can be chemically modified to adapt hydrophilic/hydrophobic balance, degradation kinetics, and physicochemical and biological properties. It may contain a lateral alkyl group or a functional group for coupling bioactive molecules to release during its degradation. In this work, we realized the chemical grafting of paclitaxel (PTX), a microtubule stabilizing anti-cancer agent on PDMMLA derivatives bio-polyesters following a Steglich esterification protocol. 1D and 2D NMR analyses validated the reaction with 10% (using 0.1 equivalent) of PTX on the copolymer PDMMLAH40-co-Hex60 (PDMMLA 40/60) and a maximal PTX grafting rate of 55% on the homopolymer PDMMLAH (PDMMLA 100/0). In vitro adhesion and cytotoxicity assays were carried out on HUVEC cells with PDMMLA 40/60, PDMMLA-PTX 30/10/60 and PLA.
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生物降解聚合物涂层在生物医学设备中的发展新进展:PDMMLA衍生物上的紫杉醇接枝
摘要生物相容性和生物可降解聚合物在医学领域有着广泛的应用。在某些情况下,生物聚合物伴随着活性药物,该活性药物以可控的方式局部递送,以改善愈合条件。聚([R,S]-3,3-二甲基苹果酸)(PDMMLA)是一种合成的两亲性可生物降解聚合物,与PLA不同,它可以进行化学改性,以适应亲水/疏水平衡、降解动力学以及物理化学和生物特性。它可能含有侧烷基或官能团,用于在降解过程中偶联生物活性分子释放。在这项工作中,我们实现了紫杉醇(PTX)的化学接枝,这是一种微管稳定抗癌剂,按照Steglich酯化方案在PDMMLA衍生物生物聚酯上进行。1D和2D NMR分析验证了在共聚物PDMMLAH40-co-Hex60(PDMMLA 40/60)上用10%(使用0.1当量)的PTX和在均聚物PDMMLAH(PDMMLA100/0)上55%的最大PTX接枝率的反应。用PDMMLA 40/60、PDMMLA-PTX 30/10/60和PLA对HUVEC细胞进行体外粘附和细胞毒性测定。
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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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