Obesity may Increase the Prevalence of Parkinson's Disease while Parkinson's may Reduce Obesity Index in Patients

Abstract

Objective: Currently Parkinson's disease is becoming more common among younger people of ages from 30-40 years. The incidence is higher among patients with higher BMI, some reports has it that Obesity is a risk factor for Parkinson’s disease while some reported that there is no relationship between obesity and Parkinson’s disease. Parkinson’s disease patient at the time of diagnosis has a above normal BMI but this goes below normal as the disease progresses. Therefore, it is important to explore the relationship between Parkinson’s disease and Obesity. Methods: 349 outpatients and inpatients with Parkinson's disease were selected from the people's Hospital affiliated to Jiangsu University from 2014.01 to 2018.12, and 64 inpatients with non-cerebrovascular disease in the same period were selected as the control group. According to HoehnYahr grade, Parkinson's patients were divided into early stage (1~2 grade), middle stage (2.5~3 grade) and late stage (4~5 grade). The height, weight, waist circumference, total cholesterol (TC), TG (TG), high density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured and recorded. The relationship between the severity of Parkinson's disease and blood lipid was evaluated. Results: BMI in patients with early Parkinson's disease was higher than that in patients with other diseases, but there was no significant difference. Blood lipids in patients with early Parkinson's disease were higher than those in normal control group and in patients with advanced Parkinson's disease. Conclusion: Obesity may increase the prevalence of Parkinson's disease, while Parkinson's may decrease the obesity index of patients with early Parkinson's disease.