Predictive Value of a Combination of the Age, Creatinine and Ejection Fraction (ACEF) Score and Fibrinogen Level in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

IF 0.9 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Innovations and Applications Pub Date : 2023-05-17 DOI:10.15212/cvia.2023.0027

Yuhao Zhao, Zong-sheng Guo, Zheng Liu, Xinchun Yang, Lei Zhao

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Abstract

Background: The purpose of this study was to explore whether consideration of FIB levels might improve the predictive value of the ACEF score in patients with ACS. Methods: A total of 290 patients with ACS were enrolled in this study. The clinical characteristics and MACE were recorded. Results: Multivariate logistic regression analysis revealed that the FIB level (odds ratio=7.798, 95%CI, 3.44–17.676, P<0.001) and SYNTAX score (odds ratio=1.034, 95%CI, 1.001–1.069, P=0.041) were independent predictors of MACE. On the basis of the regression coefficient for FIB, the ACEF-FIB was developed. The area under the ROC of the ACEF-FIB scoring system in predicting MACE after PCI was 0.753 (95%CI 0.688–0.817, P<0.001), a value greater than those for the ACEF score, SYNTAX score and Grace score (0.627, 0.637 and 0.570, respectively). Conclusion: ACEF-FIB had better discrimination ability than the other risk scores, according to ROC curve analysis, net reclassification improvement and integrated discrimination improvement.

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年龄、肌酐和射血分数（ACEF）评分和纤维蛋白原水平对急性冠状动脉综合征患者经皮冠状动脉介入治疗的预测价值

背景：本研究的目的是探讨考虑FIB水平是否可以提高ACS患者ACEF评分的预测值。方法：共有290名ACS患者参与本研究。记录临床特征和MACE。结果：多因素logistic回归分析显示，FIB水平（比值比=7.798，95%CI，3.44-17.676，P<0.001）和SYNTAX评分（比值比=1.034，95%CI为1.001-1.069，P=0.041）是MACE的独立预测因素。在FIB回归系数的基础上，开发了ACEF-FIB。ACEF-FIB评分系统预测PCI后MACE的ROC下面积为0.753（95%CI 0.688–0.817，P<0.001），大于ACEF评分、SYNTAX评分和Grace评分（分别为0.627、0.637和0.570），净重新分类改进和综合歧视改进。

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