Aging and Lung Disease.

IF 15.7 1区医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2019-11-15 DOI:10.1146/annurev-physiol-021119-034610

Soo Jung Cho, H. Stout-Delgado

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引用次数: 124

Abstract

People worldwide are living longer, and it is estimated that by 2050, the proportion of the world's population over 60 years of age will nearly double. Natural lung aging is associated with molecular and physiological changes that cause alterations in lung function, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to acute and chronic lung diseases. As the aging population rapidly grows, it is essential to examine how alterations in cellular function and cell-to-cell interactions of pulmonary resident cells and systemic immune cells contribute to a higher risk of increased susceptibility to infection and development of chronic diseases, such as chronic obstructive pulmonary disease and interstitial pulmonary fibrosis. This review provides an overview of physiological, structural, and cellular changes in the aging lung and immune system that facilitate the development and progression of disease. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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衰老与肺病。

全世界的人寿命越来越长，据估计，到2050年，世界60岁以上人口的比例将几乎翻一番。自然肺衰老与分子和生理变化有关，这些变化会导致肺功能改变、肺重塑和再生能力减弱，以及对急性和慢性肺部疾病的易感性增加。随着老龄化人口的快速增长，有必要研究肺部驻留细胞和全身免疫细胞的细胞功能和细胞间相互作用的改变如何导致感染易感性增加和慢性疾病发展的更高风险，如慢性阻塞性肺病和间质性肺纤维化。这篇综述概述了衰老肺部和免疫系统中促进疾病发展和进展的生理、结构和细胞变化。《生理学年度评论》第82卷预计最终在线出版日期为2020年2月10日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of physiology 医学-生理学

CiteScore

35.60

自引率

0.00%

发文量

期刊介绍： Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.

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