{"title":"Design and Development of Analytical Method for Deflazacort Estimation: A Robust HPLC Approach","authors":"S. Pund, Vaibhav V Changediya, V. Rajurkar","doi":"10.25258/ijpqa.14.2.21","DOIUrl":null,"url":null,"abstract":"The data show that the RP-HPLC method can accurately determine the amount of deflazacort (DEF) in compound. Validation of procedure followed ICH standards. The wavelength of estimation for deflazacort was 266 nm. Linearity was found to be 20 to 100 μg/mL for deflazacort. The %recovery for deflazacort was found to be 80 to 120%. Intraday precision of deflazacort was found to be 0.069 to 0.168% RSD. Interday precision found to be 0.0156 and 0.176% RSD .","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Quality Assurance","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25258/ijpqa.14.2.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The data show that the RP-HPLC method can accurately determine the amount of deflazacort (DEF) in compound. Validation of procedure followed ICH standards. The wavelength of estimation for deflazacort was 266 nm. Linearity was found to be 20 to 100 μg/mL for deflazacort. The %recovery for deflazacort was found to be 80 to 120%. Intraday precision of deflazacort was found to be 0.069 to 0.168% RSD. Interday precision found to be 0.0156 and 0.176% RSD .
期刊介绍：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
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