Growth hormone-releasing pituitary microadenoma overshaded by a macroadenoma: a case of double pituitary adenomas and review of the literature.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2022-06-03 DOI:10.1080/02688697.2022.2076806

Harun Demirci, Devrim Kahraman, Pelin Kuzucu, Özde Şenol, Kadriye Şerife Uğur, Mehmet Ali Ergün, Semih Keskil, Pınar Akdemir Özışık

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Abstract

Objectives: Double pituitary adenoma is a rare entity that can pose a significant challenge. The incidence of double or multiple pituitary adenomas is ∼1% in autopsy cases and 0.4-1.3% in surgical series. Its definition varies, including 'double adenomas' in the literature in contrast to 'multiple adenomas', which is more specific and suitable. While some authors require separating topographically unique tumours, others have used a looser definition of separate immunohistochemistry.

Case presentation: We presented the case of a 26-year-old patient with recurrent carpal tunnel syndrome symptoms, with double pituitary adenomas secreting growth hormone (GH) and thyroid-stimulating hormone (TSH). To date, 89 patients have been reported in the literature with symptomatic carpal tunnel syndrome, but only five had GH-TSH secretion.

Conclusions: Double adenoma resection is of great importance for ensuring successful biochemical treatment. To ensure a successful operation, a careful preoperative 3T MRI examination is of great importance.

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生长激素释放型垂体微腺瘤伴大腺瘤：一例双垂体腺瘤并文献复习。

目的双垂体腺瘤是一种罕见的实体瘤，可能会带来重大挑战。尸检病例中双发或多发垂体腺瘤的发生率为~1%，手术系列中为0.4-1.3%。它的定义各不相同，包括文献中的“双腺瘤”，而“多腺瘤”更具体、更合适。虽然一些作者要求分离拓扑结构独特的肿瘤，但其他作者对单独的免疫组织化学使用了更宽松的定义。病例介绍我们介绍了一例26岁的患者，该患者有复发性腕管综合征症状，伴有分泌生长激素（GH）和促甲状腺激素（TSH）的双垂体腺瘤。迄今为止，文献中已有89名患者出现腕管综合征症状，但只有5名患者有GH-TSH分泌。结论双腺瘤切除术对保证生化治疗的成功具有重要意义。为了确保手术成功，术前仔细的3T MRI检查至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.