Subacute thyroiditis following COVID-19 vaccination: Case presentation.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Antiviral Therapy Pub Date : 2023-10-01 DOI:10.1177/13596535231208831
Aleksandra Z Tomic, Sonja S Zafirovic, Zoran M Gluvic, Vladimir S Samardzic, Mirjana T Macvanin, Maja Lj Radunovic, Esma R Isenovic
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Abstract

Background: Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19 vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2 direct action, euthyroid sick syndrome, and immune-mediated mechanisms are all potential mechanisms of thyroid damage. It denotes thyroid gland inflammation, most commonly of viral origin, and belongs to the transitory, self-limiting thyroid gland diseases group, causing complications in approximately 15% of patients in the form of permanent hypothyroidism. Some authors say SAT is the most common thyroid disease associated with COVID-19.Purpose: The occurrence of SAT many weeks after administering the second COVID-19 vaccine is rare and has limited documentation in academic literature. This study aims to present the occurrence of SAT after administering the COVID-19 vaccine. We present the case of a 37-year-old man who developed SAT 23 days after receiving the second dose of Pfizer BioNTech's COVID-19 mRNA vaccine.Research design and study sample: Due to neck pain and an elevated body temperature (up to 38.2°C), a 37-year-old male subject presented for examination 23 days after receiving the second Pfizer BioNTech mRNA vaccine against SARS-CoV-2 viral infection. The patient denied ever having an autoimmune disease or any other disease. Painful neck palpation and a firm, slightly enlarged thyroid gland with no surrounding lymphadenopathy were identified during the exam. The heart rate was 104 beats per minute. All of the remaining physical findings were normal.Data collection and/or Analysis: Data collected during the disease are integral to the medical record.Results: Hematology and biochemistry analyses at the initial and follow-up visits revealed minor leukocytosis, normocytic anaemia, and thrombocytosis, followed by a mild increase in lactate dehydrogenase and decreased iron levels. The patient's thyroid function and morphology had recovered entirely from post-vaccine SAT.Conclusions: Results from this study emphasise the need for healthcare professionals to promptly report any case of SAT related to COVID-19 vaccination. Further investigation is warranted to understand the immunopathogenesis of COVID-19-associated thyroiditis and the impact of COVID-19 immunization on this condition.

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新冠肺炎疫苗接种后的亚急性甲状腺炎:病例介绍。
背景:亚急性甲状腺炎(SAT)是一种器官特异性疾病,包括新冠肺炎疫苗在内的各种药物都可能引发。新冠肺炎感染与甲状腺损伤和疾病有关,SARS-CoV-2直接作用、甲状腺功能正常综合征和免疫介导机制都是甲状腺损伤的潜在机制。它表示甲状腺炎症,最常见的是病毒性炎症,属于短暂性、自限性甲状腺疾病组,约15%的患者会出现永久性甲状腺功能减退的并发症。一些作者表示,SAT是与新冠肺炎相关的最常见的甲状腺疾病。目的:在接种第二剂新冠肺炎疫苗数周后,SAT的发生是罕见的,学术文献中的文献也有限。本研究旨在介绍接种新冠肺炎疫苗后SAT的发生情况。我们介绍了一名37岁男子的病例,他在接种第二剂辉瑞-BioNTech的新冠肺炎mRNA疫苗23天后出现SAT。研究设计和研究样本:由于颈部疼痛和体温升高(高达38.2°C),一名37岁的男性受试者在接种第二种针对严重急性呼吸系统综合征冠状病毒2型病毒感染的辉瑞-BioNTech信使核糖核酸疫苗23天后接受检查。该患者否认曾患有自身免疫性疾病或任何其他疾病。检查中发现颈部触诊疼痛,甲状腺肿大,周围无淋巴结肿大。心率为每分钟104次。所有剩余的身体检查结果均正常。数据收集和/或分析:在疾病期间收集的数据是医疗记录的组成部分。结果:初次和随访时的血液学和生物化学分析显示有轻微的白细胞增多、正常细胞贫血和血小板增多,随后乳酸脱氢酶轻度升高,铁水平下降。患者的甲状腺功能和形态已从疫苗接种后的SAT中完全恢复。结论:这项研究的结果强调,医护人员需要及时报告任何与新冠肺炎疫苗接种有关的SAT病例。有必要进行进一步调查,以了解COVID-19相关甲状腺炎的免疫发病机制以及新冠肺炎免疫对这种情况的影响。
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来源期刊
Antiviral Therapy
Antiviral Therapy 医学-病毒学
CiteScore
2.60
自引率
8.30%
发文量
35
审稿时长
4-8 weeks
期刊介绍: Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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