Fatemeh KhabazianZadeh, Tooba Kazemi, Samaneh Nakhaee, Patrick C Ng, Omid Mehrpour
{"title":"Acetaminophen poisoning-induced heart injury: a case-based review.","authors":"Fatemeh KhabazianZadeh, Tooba Kazemi, Samaneh Nakhaee, Patrick C Ng, Omid Mehrpour","doi":"10.1007/s40199-019-00307-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Acetaminophen (Paracetamol, APAP) poisoning is frequently implicated in self-harm. Cases of acetaminophen-associated cardiotoxicity are rare in relation to the number of patients with acetaminophen poisoning. A review of acetaminophen cardiotoxicity in 1996 concluded that there was no decisive evidence demonstrating that acetaminophen overdose has a cardiotoxic effect. This review study aimed to determine whether acetaminophen could induce heart injury.</p><p><strong>Methods: </strong>We searched for keywords of acetaminophen, paracetamol, cardiotoxicity, heart injury, heart damage, myocarditis, pericarditis, myocardial infarction, and myocardial ischemia in Web of Science, PubMed, Scopus, Embase, Google Scholar, and Persian databases. The search included articles published from January 1950 to October 2018 with no language restrictions.</p><p><strong>Results: </strong>The search yielded 64 citations in English; 36 of the articles were excluded as they were not relevant; 5 articles were excluded since they were duplicates, leaving 23 articles. Full-text articles of the 23 citations were obtained and reviewed. Myocardial infarction, heart dysfunction and failure, cardiac arrhythmias, pericarditis, heart cell necrosis, and sudden cardiac death were reported in acetaminophen overdose.</p><p><strong>Conclusions: </strong>Ddysrhythmias, heart failure, and various other cardiac effects could occur following acetaminophen induced hepatic failure. However, the evidence for direct injury on cardiac tissue is weak. Graphical abstract Potential mechanisms for cardiotoxicity of acetaminophen.</p>","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"27 2","pages":"839-851"},"PeriodicalIF":2.5000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895290/pdf/40199_2019_Article_307.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"DARU Journal of Pharmaceutical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40199-019-00307-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/11/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Acetaminophen (Paracetamol, APAP) poisoning is frequently implicated in self-harm. Cases of acetaminophen-associated cardiotoxicity are rare in relation to the number of patients with acetaminophen poisoning. A review of acetaminophen cardiotoxicity in 1996 concluded that there was no decisive evidence demonstrating that acetaminophen overdose has a cardiotoxic effect. This review study aimed to determine whether acetaminophen could induce heart injury.
Methods: We searched for keywords of acetaminophen, paracetamol, cardiotoxicity, heart injury, heart damage, myocarditis, pericarditis, myocardial infarction, and myocardial ischemia in Web of Science, PubMed, Scopus, Embase, Google Scholar, and Persian databases. The search included articles published from January 1950 to October 2018 with no language restrictions.
Results: The search yielded 64 citations in English; 36 of the articles were excluded as they were not relevant; 5 articles were excluded since they were duplicates, leaving 23 articles. Full-text articles of the 23 citations were obtained and reviewed. Myocardial infarction, heart dysfunction and failure, cardiac arrhythmias, pericarditis, heart cell necrosis, and sudden cardiac death were reported in acetaminophen overdose.
Conclusions: Ddysrhythmias, heart failure, and various other cardiac effects could occur following acetaminophen induced hepatic failure. However, the evidence for direct injury on cardiac tissue is weak. Graphical abstract Potential mechanisms for cardiotoxicity of acetaminophen.
目的：对乙酰氨基酚（APAP）中毒常与自身伤害有关。与对乙酰氨基酚中毒患者数量相关的对乙酰氨基苯酚相关心脏毒性病例很少。1996年对对乙酰氨基酚心脏毒性的审查得出结论，没有决定性的证据表明过量服用乙酰氨基酚具有心脏毒性作用。本综述研究旨在确定对乙酰氨基酚是否会导致心脏损伤。方法：我们在Web of Science、PubMed、Scopus、Embase、Google Scholar和Persian数据库中搜索对乙酰氨基酚、扑热息痛、心脏毒性、心脏损伤、心脏损害、心肌炎、心包炎、心肌梗死和心肌缺血的关键词。搜索包括1950年1月至2018年10月发表的文章，没有语言限制。结果：检索得到64篇英文引文；其中36条因不相关而被排除在外；5篇文章被排除在外，因为它们是重复的，剩下23篇文章。获得并审查了23篇引文的全文文章。对乙酰氨基酚过量引起心肌梗死、心脏功能障碍和衰竭、心律失常、心包炎、心脏细胞坏死和心源性猝死。结论：对乙酰氨基酚诱导的肝功能衰竭可能会出现心律失常、心力衰竭和其他各种心脏影响。然而，直接损伤心脏组织的证据并不充分。图形摘要对乙酰氨基酚心脏毒性的潜在机制。
期刊介绍：
DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment.
The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
