Antibodies Reactive to Leptin in Adults with Type 2 Diabetes and Its Relationship with Clinical, Metabolic and Cardiovascular Risk Parameters.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2024-01-02 Epub Date: 2024-01-04 DOI:10.1080/07435800.2023.2270763

Ana B Vargas-Antillón, Mildren Porchas-Quijada, Eloy A Zepeda-Carrillo, Rafael Torres-Valadez, José F Muñoz-Valle, Rafael Vázquez-Solórzano, Elia Valdés-Miramontes, Luis A Hernández-Palma, Zyanya Reyes-Castillo

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Abstract

Background and aims: Patients with obesity and type 2 diabetes (T2D) have shown alterations in the affinity of IgG anti-leptin antibodies which are possibly related to metabolic alterations. In the present exploratory study, we analyzed serum samples from adults with T2D classified by body mass index (BMI) and evaluated the relationship of IgG anti-leptin antibodies with body composition, metabolic and cardiovascular risk parameters.

Methods: Serum IgG anti-leptin antibodies (total, free and immune complexes fractions) were measured by in-house ELISA. Body composition, metabolic biomarkers (glucose, glycated hemoglobin, lipid profile, insulin, leptin) and cardiometabolic risk indexes (AIP, HOMA-IR, HOMA-ß) were evaluated in one hundred T2D patients.

Results: Patients with T2D and obesity presented a decrease in the percentage of IgG anti-leptin immune complexes compared to patients with T2D and overweight (p < 0.0053). Negative correlations of IgG anti-leptin immune complexes with triglycerides (TG) (r=-0.412, p = 0.023) and VLDL-C (r=-0.611, p = 0.017) were found in normal weight T2D patients. Free IgG anti-leptin antibodies correlated positively with TC (r = 0.390, p = 0.032) and LDL-C (r = 0.458, p = 0.011) in overweight individuals with T2D. Finally, total IgG anti-leptin antibodies correlated positively with leptin hormone levels (r = 0.409, p = 0.024) and negatively with HOMA-IR (r =-0.459, p = 0.012) in T2D patients with obesity.

Conclusions: The decrease of IgG anti-leptin immune complexes observed in patients with T2D and obesity suggests a reduction in antibody affinity to the hormone that may impact its transport and signaling, lipid, lipoprotein and insulin metabolism.

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成人2型糖尿病患者对瘦素反应的抗体及其与临床、代谢和心血管风险参数的关系。

背景和目的：肥胖和2型糖尿病（T2D）患者的IgG抗瘦素抗体亲和力发生了变化，这可能与代谢变化有关。在本探索性研究中，我们分析了按体重指数（BMI）分类的成人T2D患者的血清样本，并评估了IgG抗瘦素抗体与身体成分、代谢和心血管风险参数的关系。方法：采用ELISA法测定血清IgG抗瘦素抗体（总抗体、游离抗体和免疫复合物组分）。对100名T2D患者的身体组成、代谢生物标志物（葡萄糖、糖化血红蛋白、脂质概况、胰岛素、瘦素）和心脏代谢风险指数（AIP、HOMA-IR、HOMA-ß）进行了评估。结果：与T2D和超重患者相比，T2D和肥胖患者IgG抗瘦素免疫复合物的百分比降低（p r=-0.412，p = 0.023）和VLDL-C（r=-0.611，p = 0.017）在正常体重的T2D患者中发现。游离IgG抗瘦素抗体与TC呈正相关（r = 0.390，p = 0.032）和LDL-C（r = 0.458，p = 0.011）。最后，总IgG抗瘦素抗体与瘦素激素水平呈正相关（r = 0.409，p = 0.024）与HOMA-IR呈负相关（r=-0.459，p = 0.012）。结论：在T2D和肥胖患者中观察到的IgG抗瘦素免疫复合物的减少表明抗体对激素的亲和力降低，这可能影响其转运和信号传导、脂质、脂蛋白和胰岛素代谢。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

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