Possibilities of skin coat color-dependent risks and risk factors of squamous cell carcinoma and deafness of domestic cats inferred via RNA-seq data

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-21 DOI:10.1111/gtc.13076

Akinori Awazu, Daigo Takemoto, Kaichi Watanabe, Naoaki Sakamoto

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Abstract

The transcriptome data of skin cells from domestic cats with brown, orange, and white coats were analyzed using a public database to investigate the possible relationship between coat color-related gene expression and squamous cell carcinoma risk, as well as the mechanism of deafness in white cats. We found that the ratio of the expression level of genes suppressing squamous cell carcinoma to that of genes promoting squamous cell carcinoma might be considerably lower than the theoretical estimation in skin cells with orange and white coats in white-spotted cat. We also found the possibility of the frequent production of KIT lacking the first exon (d1KIT) in skin cells with white coats, and d1KIT production exhibited a substantial negative correlation with the expression of SOX10, which is essential for melanocyte formation and adjustment of hearing function. Additionally, the production of d1KIT was expected to be due to the insulating activity of the feline endogenous retrovirus 1 (FERV1) LTR in the first intron of KIT by its CTCF binding sequence repeat. These results contribute to basic veterinary research to understand the relationship between cat skin coat and disease risk, as well as the underlying mechanism.

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通过RNA-seq数据推断家猫鳞状细胞癌和耳聋的皮肤颜色依赖性风险和危险因素的可能性。

使用公共数据库分析了棕色、橙色和白色皮毛家猫皮肤细胞的转录组数据，以研究皮毛颜色相关基因表达与鳞状细胞癌风险之间的可能关系，以及白猫耳聋的机制。我们发现，在白斑猫的橙色和白色皮肤细胞中，抑制鳞状细胞癌的基因与促进鳞状细胞癌基因的表达水平的比率可能远低于理论估计。我们还发现，在有白大褂的皮肤细胞中，缺乏第一外显子（d1KIT）的KIT可能频繁产生，并且d1KIT的产生与SOX10的表达呈显著负相关，SOX10对黑素细胞的形成和听力功能的调节至关重要。此外，预计d1KIT的产生是由于猫内源性逆转录病毒1（FERV1）LTR通过其CTCF结合序列重复在KIT的第一内含子中的绝缘活性。这些结果有助于兽医基础研究，以了解猫皮毛与疾病风险之间的关系以及潜在机制。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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