The Role of Extracellular Vesicles in Efferocytosis.

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0113895575247690230926113455

Susan Panahi, Zohreh Yazdi, Mahboubeh Sanchouli, Fatemehsadat Sajadi, Fateme Motavasselian, Hedyeh Maghareh Abed, Zahra Beygi, Seyed Mohammad Gheibihayat

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Abstract

Efferocytosis is the physiological process of phagocytic clearance of apoptotic cells by both professional phagocytic cells, such as macrophages, and non-professional phagocytic cells, such as epithelial cells. This process is crucial for maintaining tissue homeostasis in normal physiology. Any defects in efferocytosis can lead to pathological consequences and result in inflammatory diseases. Extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic vesicles (ApoVs), play a crucial role in proper efferocytosis. These EVs can significantly impact efferocytosis by affecting the polarization of macrophages and impacting calreticulin (CRT), TAM receptors, and MFG-E8. With further knowledge of these effects, new treatment strategies can be proposed for many inflammatory diseases caused by efferocytosis disorders. This review article aims to investigate the role of EVs during efferocytosis and its potential clinical applications in inflammatory diseases.

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细胞外小泡在胞吐中的作用。

胞吐作用是专业吞噬细胞（如巨噬细胞）和非专业吞噬细胞，如上皮细胞对凋亡细胞进行吞噬清除的生理过程。这一过程对于维持正常生理中的组织稳态至关重要。泡腾细胞增多症的任何缺陷都可能导致病理后果，并导致炎症性疾病。细胞外小泡（EV），包括外泌体、微泡（MV）和凋亡小泡（ApoVs），在适当的泡腾中起着至关重要的作用。这些EVs可以通过影响巨噬细胞的极化和影响钙网蛋白（CRT）、TAM受体和MFG-E8来显著影响泡腾增多症。随着对这些影响的进一步了解，可以为泡腾细胞增多症引起的许多炎症性疾病提出新的治疗策略。本文旨在探讨EVs在泡腾细胞增多症中的作用及其在炎症性疾病中的潜在临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.