Gastric Polyps in Familial Adenomatous Polyposis Portuguese Patients: The First Western Cohort with Asian Features.

IF 3.5 4区 医学 Q3 CELL BIOLOGY Pathobiology Pub Date : 2024-01-01 Epub Date: 2023-10-18 DOI:10.1159/000534571
Diana Baptista, Marco Fernandes, Monica Garrido, Fabiana Sousa, Rui Morais, José Garcia-Pelaez, Roberto Silva, Dina Leitão, Manuela Baptista, José Barbosa, Fátima Carneiro, Irene Gullo
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Abstract

Introduction: Chronic atrophic gastritis may contribute to gastric polyps (GP) phenotype in familial adenomatous polyposis (FAP). Considering the high prevalence of Helicobacter pylori (HP) infection in Portugal, we aim to characterize GP in a series of Portuguese patients.

Methods: In a retrospectively selected series of 53 FAP patients, clinical data and histopathological features of GP and background gastric mucosa were studied. SPSS (27.0) was used for statistical analysis.

Results: Thirteen patients (24.5%) developed fundic gland polyps (FGP), seven (13.2%) gastric adenomas (GA), and ten (18.9%) both FGP and GA. Out of 100 GP, four were hyperplastic polyps, 58 FGP (24 with dysplasia), 35 intestinal-type GA (intGA), and three foveolar-type GA (fovGA). IntGA were larger (60% >7 mm, p = 0.03), occurred predominantly in the distal stomach (66.7%, p = 0.024), in patients harboring gastric intestinal metaplasia (IM) (86.7%, p < 0.001), and duodenal adenomas (86.7%, p < 0.001).

Conclusion: This is the first Western series showing high prevalence of intGA in FAP patients, comparable to Asian cohorts. HP infection and chronic atrophic gastritis/intestinal metaplasia are likely responsible for this difference, with risk of neoplastic transformation and management implications. Biopsy/excision of GP >7 mm in the distal stomach and in patients harboring gastric intestinal metaplasia/duodenal adenomas should be considered.

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家族性腺瘤性息肉病葡萄牙患者的胃息肉:第一个具有亚洲特征的西方队列。
引言:慢性萎缩性胃炎可能导致家族性腺瘤性息肉病(FAP)的胃息肉(GP)表型。考虑到葡萄牙幽门螺杆菌(HP)感染的高患病率,我们旨在对一系列葡萄牙患者的GP进行表征。方法:回顾性选择53例FAP患者,对GP的临床资料、组织病理学特征和背景胃黏膜进行研究。统计分析采用SPSS(27.0)软件。结果:13例(24.5%)发生基底腺息肉(FGP),7例(13.2%)发生胃腺瘤(GA),10例(18.9%)同时发生FGP和GA。在100例GP中,4例为增生性息肉,58例为FGP(24例伴发育不良),35例为肠型GA(intGA),3例为凹型GA(fovGA)。IntGA较大(60%>7mm,p=0.03),主要发生在远端胃(66.7%,p=0.024),胃肠化生(IM)患者(86.7%,p7mm,在远端胃,以及胃肠化生/十二指肠腺瘤患者应予以考虑。
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来源期刊
Pathobiology
Pathobiology 医学-病理学
CiteScore
8.50
自引率
0.00%
发文量
47
审稿时长
>12 weeks
期刊介绍: ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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