Animal models of hepatitis E infection: Advances and challenges

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Hepatobiliary & Pancreatic Diseases International Pub Date : 2023-10-10 DOI:10.1016/j.hbpd.2023.10.001
Ze Xiang , Xiang-Lin He , Chuan-Wu Zhu , Jia-Jia Yang , Lan Huang , Chun Jiang , Jian Wu
{"title":"Animal models of hepatitis E infection: Advances and challenges","authors":"Ze Xiang ,&nbsp;Xiang-Lin He ,&nbsp;Chuan-Wu Zhu ,&nbsp;Jia-Jia Yang ,&nbsp;Lan Huang ,&nbsp;Chun Jiang ,&nbsp;Jian Wu","doi":"10.1016/j.hbpd.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Hepatitis E virus (HEV) is one of the leading causes of </span>acute viral hepatitis worldwide. Although most of HEV infections are asymptomatic, some patients will develop the </span>symptoms<span>, especially pregnant women, the elderly, and patients with preexisting liver diseases, who often experience anorexia, nausea, vomiting, malaise, abdominal pain, and jaundice. HEV infection may become chronic in immunosuppressed individuals. In addition, HEV infection can also cause several extrahepatic manifestations. HEV exists in a wide range of hosts in nature and can be transmitted across species. Hence, animals susceptible to HEV can be used as models. The establishment of animal models is of great significance for studying HEV transmission, clinical symptoms, extrahepatic manifestations, and therapeutic strategies, which will help us understand the pathogenesis, prevention, and treatment of hepatitis E. This review summarized the animal models of HEV, including pigs, monkeys, rabbits, mice, rats, and other animals. For each animal species, we provided a concise summary of the HEV genotypes that they can be infected with, the cross-species transmission pathways, as well as their role in studying extrahepatic manifestations, prevention, and treatment of HEV infection. The advantages and disadvantages of these animal models were also emphasized. This review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.</span></p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 2","pages":"Pages 171-180"},"PeriodicalIF":3.6000,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepatobiliary & Pancreatic Diseases International","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1499387223001753","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis worldwide. Although most of HEV infections are asymptomatic, some patients will develop the symptoms, especially pregnant women, the elderly, and patients with preexisting liver diseases, who often experience anorexia, nausea, vomiting, malaise, abdominal pain, and jaundice. HEV infection may become chronic in immunosuppressed individuals. In addition, HEV infection can also cause several extrahepatic manifestations. HEV exists in a wide range of hosts in nature and can be transmitted across species. Hence, animals susceptible to HEV can be used as models. The establishment of animal models is of great significance for studying HEV transmission, clinical symptoms, extrahepatic manifestations, and therapeutic strategies, which will help us understand the pathogenesis, prevention, and treatment of hepatitis E. This review summarized the animal models of HEV, including pigs, monkeys, rabbits, mice, rats, and other animals. For each animal species, we provided a concise summary of the HEV genotypes that they can be infected with, the cross-species transmission pathways, as well as their role in studying extrahepatic manifestations, prevention, and treatment of HEV infection. The advantages and disadvantages of these animal models were also emphasized. This review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
戊型肝炎感染的动物模型:进展和挑战。
戊型肝炎病毒(HEV)是世界范围内引起急性病毒性肝炎的主要原因之一。尽管大多数HEV感染是无症状的,但一些患者会出现症状,尤其是孕妇、老年人和已有肝病的患者,他们经常出现厌食、恶心、呕吐、不适、腹痛和黄疸。HEV感染可能在免疫抑制的个体中变成慢性。此外,戊型肝炎病毒感染还可引起多种肝外表现。HEV存在于自然界中广泛的宿主中,可以跨物种传播。因此,对HEV敏感的动物可以用作模型。动物模型的建立对研究戊型肝炎病毒的传播、临床症状、肝外表现和治疗策略具有重要意义,有助于我们了解戊型肝炎的发病机制、预防和治疗。对于每种动物,我们简要总结了它们可能感染的HEV基因型、跨物种传播途径,以及它们在研究肝外表现、预防和治疗HEV感染中的作用。还强调了这些动物模型的优点和缺点。这篇综述为增强当前对HEV动物模型研究现状的理解提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
5.40
自引率
6.10%
发文量
152
审稿时长
3.0 months
期刊介绍: Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.
期刊最新文献
Chinese contributions to liver transplantation. "No-donor" liver transplantation. No-touch recipient hepatectomy in liver transplantation for liver malignancies: A state-of-the-art review. Research progress of ischemia-free liver transplantation. Sequential living donor liver transplantation after liver resection optimizes outcomes for patients with high-risk hepatocellular carcinoma.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1