A Case of Superficial Angiomyxoma Localized on the Nipple in a 12-Year-Old Korean Female.

Abstract

: A 12-year-old Korean female presented with a 1-month of tender group of reddish 1 to 3 mm sized dome-shaped papules on the left nipple (Fig. 1). She had no similar lesion on the other site and no family history of similar skin lesions. She had neither pigmented lesions in her skin or mucous membranes, nor any other known medical conditions. The lesion was totally excised and histopathologic examination showed well-circumscribed, non-encapsulated myxoid tumor (Fig. 2A), and stromal mucin was positive for Alcian blue staining (Fig. 2B). Tumor consisted of spindle and stellate cells as well as numerous thin-walled small vessels in the myxoid stroma (Fig. 2C). Immunohistological staining revealed tumor cells were positive for vimentin (Fig. 2D), and positive for α -smooth muscle actin ( α -SMA) (Fig. 2E). Endothelial cells of blood vessels were CD34 positive, but tumor cells were negative (Fig. 2F). The patient was diagnosed with superficial angiomyxoma (SAM) and there was no sign of recurrence after 12 months of follow-up. SAM is an