Optical Coherence Tomography Angiography for Evaluation of Conjunctival Vessels in Dry Eyes.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY Journal of Ophthalmology Pub Date : 2023-10-14 eCollection Date: 2023-01-01 DOI:10.1155/2023/1609332
TongFeng Cui, HongYan Sun, ZiZhong Hu, YaBo Shi, Jiang Zhu, ManMan Jin, Bing Qin
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Abstract

Objective: This study aimed to evaluate conjunctival vessels in patients with dry eye disease (DED) using optical coherence tomography angiography (OCTA).

Methods: This was a cross-sectional, observational clinical study. Twenty-three eyes of 18 patients with DED and 28 eyes of 23 healthy controls were included for examination in this study. The evaluation included the application of an Ocular Surface Disease Index Questionnaire, Schirmer Basic Secretion Test, and anterior OCTA targeting the temporal conjunctiva. AngioTool software was used to quantify the total vessel length and vessel density in the 3 × 3 mm temporal region of interest.

Results: Blood vessel density measurements were compared across the OCTA systems. The total vessel length within the conjunctiva of the DED group (4799.34 ± 834.36) exceeded that of the control eye (3864.89 ± 1455.70) group (P < 0.05). However, the difference in vessel density between the two groups was not statistically significant.

Conclusion: Measurement and analysis of conjunctival blood vessels using OCTA exhibited robust repeatability. In dry eyes, the total number of conjunctival blood vessels increased in accordance with disease severity. Hypoxia of conjunctival tissue may be an important cause of dry eye disease.

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光学相干断层扫描血管造影术用于评估干眼结膜血管。
目的:本研究旨在利用光学相干断层扫描血管造影术(OCTA)评估干眼病(DED)患者的结膜血管。方法:这是一项横断面观察性临床研究。本研究包括18名DED患者的23只眼睛和23名健康对照的28只眼睛进行检查。评估包括应用眼表疾病指数问卷、Schirmer基础分泌物测试和针对颞结膜的前OCTA。AngioTool软件用于量化3 × 3. mm感兴趣的时间区域。结果:比较了OCTA系统的血管密度测量结果。DED组结膜内的总血管长度(4799.34 ± 834.36)超过对照眼(3864.89 ± 1455.70)组(P 结论:OCTA对结膜血管的测量和分析具有较强的重复性。在干眼症中,结膜血管的总数随着疾病的严重程度而增加。结膜组织缺氧可能是干眼症的一个重要原因。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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