Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI:10.1155/2023/5044451
Xinyu Chen, Zhuolu Hao, Nannan Wang, Jia Zhu, Honggang Yi, Shaowen Tang
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引用次数: 0

Abstract

Methods: The PRISMA statement was strictly followed, and the protocol was registered in PROSPERO (CRD42022339317). The PICOS framework was used: patients received antituberculosis treatment, UGTs polymorphisms (mutants), UGTs polymorphisms (wild), AT-DILI, and case-control studies. Eligible studies were searched through nine databases up to April 27, 2022. The study's qualities were assessed by the revised Little's recommendations. Meta-analysis was conducted with a random-effects model using odds ratios (ORs) with 95% confidence intervals (95% CIs) as the effect size.

Results: Twelve case-control studies with 2128 cases and 4338 controls were included, and 32 single nucleotide polymorphisms (SNPs) in the seven UGT genes have been reported in Chinese and Korean. All studies were judged as high quality. The pooled results indicated that UGT1A1 rs3755319 (AC vs. AA, OR = 1.454, 95% CI: 1.100-1.921, P = 0.009), UGT2B7 rs7662029 (G vs. A, OR = 1.547, 95% CI: 1.249-1.917, P < 0.0001; GG + AG vs. AA, OR = 2.371, 95% CI: 1.779-3.160, P < 0.0001; AG vs. AA, OR = 2.686, 95% CI: 1.988-3.627, P < 0.0001), and UGT2B7 rs7439366 (C vs. T, OR = 0.585, 95% CI: 0.477-0.717, P < 0.0001; CC + TC vs. TT, OR = 0.347, 95% CI: 0.238-0.506, P < 0.0001; CC vs. TC + TT, OR = 0.675, 95% CI: 0.507-0.898, P = 0.007) might be associated with the risk of AT-DILI.

Conclusions: The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion should be interpreted with caution due to the low number of studies and the relatively small sample size.

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UDP葡糖醛酸转移酶基因多态性与抗结核药物性肝损伤易感性的系统评价和荟萃分析。
方法:严格遵守PRISMA声明,并在PROSPERO(CRD42022339317)中注册该方案。使用PICOS框架:患者接受抗结核治疗、UGTs多态性(突变体)、UGTss多态性(野生型)、AT-DILI和病例对照研究。截至2022年4月27日,通过九个数据库搜索符合条件的研究。这项研究的质量通过修订后的利特尔建议进行了评估。使用优势比(OR)和95%置信区间(95%CI)作为效应大小的随机效应模型进行荟萃分析。结果:纳入了12项病例对照研究,涉及2128例病例和4338例对照,中国和韩国的7个UGT基因中有32个单核苷酸多态性(SNPs)。所有研究都被认为是高质量的。合并结果表明UGT1A1 rs3755319(AC与AA,OR = 1.454,95%置信区间:1.100-1.921,P = 0.009),UGT2B7 rs7662029(G与A,OR = 1.547,95%置信区间:1.249-1.917,P P P P P P = 结论:UGT1A1 rs3755319、UGT2B7 rs7662029、UGT2 B7 rs7439366多态性与AT-DILI易感性显著相关。然而,由于研究数量较少,样本量相对较小,因此应谨慎解释这一结论。
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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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