Role of autoantibodies targeting interferon type 1 in COVID-19 severity: A systematic review and meta-analysis

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-10-14 DOI:10.1016/j.jtauto.2023.100219
Abolfazl Akbari , Alireza Hadizadeh , Mahdi Amiri , Neshat Najaf Najafi , Zahra Shahriari , Tannaz Jamialahmadi , Amirhossein Sahebkar
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Abstract

Introduction

Impairment of the type I interferon (IFN–I) signaling pathway is associated with increased severity of COVID-19 disease. Here we have undertaken a systematic review and meta = analysis on the association between the severity of COVID-19 and IFN-1 autoantibodies (AAbs; aIFN-1, aIFN-α, aIFN-ω, and aIFN-β).

Methods

Four databases, including Medline [PubMed], Embase, Web of Science, and Scopus, were systematically searched to find papers on the role of aIFN-1 and its subtype AAbs in the severity of COVID-19 infection. Data on the prevalence of aIFN-1, aIFN-α, aIFN-ω, and aIFN-β were pooled using random- or fixed-effects models. Subgroup analysis was performed based on disease severity. Odds ratios (OR) for COVID-19 disease outcome, including length of hospital stay, ICU admission and death, were calculated in relation to positive or negative plasma IFN-1 AAbs.

Results

A total of 33 studies with 13023 patients were included. The overall prevalence of circulating aIFN-1, aIFN-α, and aIFN-ω AAbs was 17.8 % [13.8, 22.8], 7.2 % [4.7, 10.9], and 4.4 % [2.1, 8.6], respectively, and the overall prevalence of neutralizing aIFN-1, aIFN-α, aIFN-ω, and aIFN-β AAbs was 7.1 % [4.9, 10.1], 7.5 % [5.9, 9.5], 8.0 % [5.7, 11.1] and 1.2 % [0.4, 3.5], respectively. Circulating aIFN-α (OR = 4.537 [2.247, 9.158]), neutralizing aIFN-α (O = 17.482 [8.899, 34.342]), and neutralizing aIFN-ω (OR = 12.529 [7.397, 21.222]) were significantly more frequent in critical/severe patients than in moderate/mild patients (p < 0.001 for all). Anti–IFN–1 was more common in male subjects (OR = 2.248 [1.366, 3.699], p = 0.001) and two COVID-19 outcomes including ICU admission (OR = 2.485 [1.409, 4.385], p = 0.002) and death (OR = 2.593 [1.199, 5.604], p = 0.015) occurred more frequently in patients with positive anti–IFN–1.

Conclusion: aIFN-1 and its subtypes AAbs are associated with severe and critical COVID-19 disease and may be a predictive marker for a poor prognosis, particularly in men.

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靶向干扰素1型自身抗体在新冠肺炎严重程度中的作用:系统综述和荟萃分析。
简介:I型干扰素(IFN-I)信号通路的损伤与新冠肺炎疾病的严重程度增加有关。在此,我们对新冠肺炎严重程度与IFN-1自身抗体(AAbs;aIFN-1、aIFN-α、aIFA-ω和aIFN-β)之间的关系进行了系统回顾和meta分析。方法:四个数据库,包括Medline[PubMed]、Embase、Web of Science和Scopus,系统检索了关于aIFN-1及其亚型AAbs在新冠肺炎感染严重程度中的作用的论文。关于aIFN-1、aIFN-α、aIFN-ω和aIFN-β患病率的数据使用随机或固定效应模型进行汇总。根据疾病严重程度进行亚组分析。计算新冠肺炎疾病结果的比值比(OR),包括住院时间、入住ICU和死亡,与血浆IFN-1 AAbs阳性或阴性相关。结果:共纳入33项研究,涉及13023名患者。循环aIFN-1、aIFN-α和aIFN-ωAAbs的总患病率分别为17.8%[13.8,22.8]、7.2%[4.7,109]和4.4%[2.1,8.6],中和性aIFN-1、aIFN-α、aIFM-ω和aIFN-βAAbs的总体患病率分别是7.1%[4.9,110.1]、7.5%[5.9,9.5]、8.0%[5.7,111]和1.2%[0.4,3.5]。循环aIFN-α(OR=4.537[2.247,9.158])、中和aIFN-β(O=17.482[8.899,34.342])和中和aIFNω(OR=12.529[7.397,22.222])在危重/重症患者中的发生率明显高于中轻度患者(p
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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